Diterpenoids from the roots of Euphorbia fischeriana and their inhibitory effects on α-glucosidase

Chemical investigation has been performed on the roots of Euphorbia fischeriana, a traditional Chinese medicine. Three diterpenoids were obtained using various chromatographic techniques, and their structures were determined by spectroscopic data including HRESIMS, 1D NMR, 2D NMR, ECD, and calculate...

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Bibliographic Details
Published in:Journal of asian natural products research 2018-10, Vol.20 (10), p.977-984
Main Authors: Wei, Yun-Long, Yu, Zhen-Long, Huo, Xiao-Kui, Tian, Xiang-Ge, Feng, Lei, Huang, Shan-Shan, Deng, Sa, Ma, Xiao-Chi, Jia, Jing-Ming, Wang, Chao
Format: Article
Language:English
Subjects:
diterpenoids
Euphorbia fischeriana
Euphorbiaceae
α-glucosidase
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Summary:Chemical investigation has been performed on the roots of Euphorbia fischeriana, a traditional Chinese medicine. Three diterpenoids were obtained using various chromatographic techniques, and their structures were determined by spectroscopic data including HRESIMS, 1D NMR, 2D NMR, ECD, and calculated ECD, which gave two new diterpenoids, daphnane type (1) and ent-pimarene type (3). Additionally, the isolated compounds (1-3) displayed moderate inhibitory effects against α-glucosidase in an in vitro bioassay.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2017.1367923