Diterpenoids from the roots of Euphorbia fischeriana and their inhibitory effects on α-glucosidase

Chemical investigation has been performed on the roots of Euphorbia fischeriana, a traditional Chinese medicine. Three diterpenoids were obtained using various chromatographic techniques, and their structures were determined by spectroscopic data including HRESIMS, 1D NMR, 2D NMR, ECD, and calculate...

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Published in:Journal of asian natural products research 2018-10, Vol.20 (10), p.977-984
Main Authors: Wei, Yun-Long, Yu, Zhen-Long, Huo, Xiao-Kui, Tian, Xiang-Ge, Feng, Lei, Huang, Shan-Shan, Deng, Sa, Ma, Xiao-Chi, Jia, Jing-Ming, Wang, Chao
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Language:English
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diterpenoids
Euphorbia fischeriana
Euphorbiaceae
α-glucosidase
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cited_by cdi_FETCH-LOGICAL-c281t-f63077bd9df2eae5c4dd3b7cfdd6daae9bf46feb145ed50f8a7a4f48af6544763
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container_title Journal of asian natural products research
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creator Wei, Yun-Long
Yu, Zhen-Long
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Jia, Jing-Ming
Wang, Chao
description Chemical investigation has been performed on the roots of Euphorbia fischeriana, a traditional Chinese medicine. Three diterpenoids were obtained using various chromatographic techniques, and their structures were determined by spectroscopic data including HRESIMS, 1D NMR, 2D NMR, ECD, and calculated ECD, which gave two new diterpenoids, daphnane type (1) and ent-pimarene type (3). Additionally, the isolated compounds (1-3) displayed moderate inhibitory effects against α-glucosidase in an in vitro bioassay.
doi_str_mv 10.1080/10286020.2017.1367923
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subjects diterpenoids
Euphorbia fischeriana
Euphorbiaceae
α-glucosidase
title Diterpenoids from the roots of Euphorbia fischeriana and their inhibitory effects on α-glucosidase
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