Two new secolignans from the roots of Urtica fissa

Two new secolignans, 3,4-trans-3-hydroxymethyl-4-[bis(4-hydroxy-3- methoxyphenyl)methyl]butyrolactone (1) and 3,4-trans-3-hydroxymethyl-4- [bis(3,4-dimethoxyphenyl)methyl]butyrolactone (2) have been isolated from the roots of Urtica fissa E.Pritz. Their structures were determined on the basis of spe...

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Bibliographic Details
Published in:Journal of asian natural products research 2019-02, Vol.21 (2), p.165-170
Main Authors: Lu, Xuan, Li, Xue-Qing, Qin, Hai-Hong, Feng, Bao-Min, Cheng, Xing-Hua, Yang, Qing-Xiong, Yu, Da-Yong, Shi, Li-Ying, Yu, Zong-Xia, Fang, Xue-Xun
Format: Article
Language:English
Subjects:
Butyrolactone
neuraminidases
NMR
Nuclear magnetic resonance
Roots
Secolignans
structual analysis
Urtica fissa
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Summary:Two new secolignans, 3,4-trans-3-hydroxymethyl-4-[bis(4-hydroxy-3- methoxyphenyl)methyl]butyrolactone (1) and 3,4-trans-3-hydroxymethyl-4- [bis(3,4-dimethoxyphenyl)methyl]butyrolactone (2) have been isolated from the roots of Urtica fissa E.Pritz. Their structures were determined on the basis of spectroscopic methods, especially 1 H NMR, 13 C NMR, 2D NMR, and HR-ESI-MS. The inhibitory effects on N1 and N2, two subtypes of neuraminidases (NAs), of these two compounds were assayed.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2017.1411347