Cytotoxic constituents from Isotrema tadungense

In our search for cytotoxic constituents from Vietnamese plants, the methanolic extract of Isotrema tadungense was found to exhibit significant cytotoxic effect. Subsequent phytochemical investigation of ethyl acetate fractions of this plant led to isolation of 11 compounds including one new arylben...

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Bibliographic Details
Published in:Journal of asian natural products research 2021-05, Vol.23 (5), p.491-497
Main Authors: Truong, Luu Hong, Cuong, Nguyen Hieu, Dang, Tran Huu, Hanh, Nguyen Thi My, Thi, Vien Le, Tran Thi Hong, Hanh, Tran Hong Quang, Nguyen, Hai Dang, Nguyen Xuan, Cuong, Nguyen Hoai, Nam, Minh, Chau Van
Format: Article
Language:English
Subjects:
Acetic acid
Amides
Antineoplastic Agents - pharmacology
aristolochiaceae
aristololactam
arylbenzofuran
Constituents
Cytotoxicity
Ethyl acetate
HeLa Cells
Humans
Isotrema tadungense
lignanamide
Molecular Structure
NMR
Nuclear magnetic resonance
phenolic amide
Phenolic compounds
Phenols
Plant Extracts
Toxicity
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Summary:In our search for cytotoxic constituents from Vietnamese plants, the methanolic extract of Isotrema tadungense was found to exhibit significant cytotoxic effect. Subsequent phytochemical investigation of ethyl acetate fractions of this plant led to isolation of 11 compounds including one new arylbenzofuran rhamnoside namely aristolochiaside (1), two aristololactams (2 and 3), three lignanamides (4-6) and five phenolic amides (7-11). Their structures were elucidated by 1 D and 2 D NMR and HR-QTOF-MS experiments. Among the isolated compounds, aristolochiaside (1), aristolactam AIIIa (2) and N-trans-sinapoyltyramine (10) exhibited strong and selective cytotoxicity on the HeLa human cancer cell line with IC 50 values of 7.59 ± 1.03, 8.51 ± 1.73 and 9.77 ± 1.25 μM, respectively.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2020.1739661