A new prenylated coumarin diglycoside with insulin-release promoting activity from Clausena dunniana

A new prenylated coumarin diglycoside, 6-prenylcoumarin-7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (1) and five known flavonoid glycosides (2-6) were isolated from the leaves and stems of Clausena dunniana. The structures of these isolates were elucidated based on comprehensive MS, UV, IR, and...

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Bibliographic Details
Published in:Journal of asian natural products research 2021-04, Vol.23 (4), p.385-391
Main Authors: Cao, Nan-Kai, Zhu, Si-Si, Chen, Yue-Mei, Ma, Xiao-Li, Zhao, Ming-Bo, Li, Jun, Tu, Peng-Fei, Jiang, Yong
Format: Article
Language:English
Subjects:
chemical constituents
Clausena
Clausena dunniana
Coumarin
coumarin glycoside
Coumarins - pharmacology
Data analysis
Flavone glycosides
flavonoid glycosides
Flavonoids
Glycosides
Glycosides - pharmacology
Insulin
insulin-release promoting activity
Insulins
Molecular Structure
NMR
Nuclear magnetic resonance
Rutaceae
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Summary:A new prenylated coumarin diglycoside, 6-prenylcoumarin-7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (1) and five known flavonoid glycosides (2-6) were isolated from the leaves and stems of Clausena dunniana. The structures of these isolates were elucidated based on comprehensive MS, UV, IR, and NMR spectroscopic data analysis and comparison with the data reported in literature. Compounds 2-6 are obtained from the title plant for the first time. All these isolates were evaluated for their insulin-release promoting effects, and compounds 1, 2, and 4 exhibited significant activities (2.0 to 3.3-fold higher in comparison with the control, p 
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2020.1810671