Generation of tryptamine derivatives through biotransformation by Diaporthe sp

Three new tryptamine derivatives diaporols T-V (1-3) were isolated by adding tryptamine into the culture of Diaporthe sp., a fungus obtained from the leaves of Rhizophora stylosa. The structures of these compounds were elucidated by NMR spectroscopy and high resolution mass spectroscopic data. Among...

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Bibliographic Details
Published in:Journal of asian natural products research 2021-12, Vol.23 (12), p.1164-1170
Main Authors: Chen, Chao-Jun, Li, Dan, Yu, Kang-Ying, Zhou, Ming-Ming
Format: Article
Language:English
Subjects:
Biotransformation
Cell culture
Cytotoxicity
Diaporthe
Diaporthe sp
Fungi
Magnetic resonance spectroscopy
Mass spectroscopy
Molecular Structure
NMR
NMR spectroscopy
Nuclear magnetic resonance
Rhizophoraceae
Tryptamine
Tryptamines
Tryptamines - pharmacology
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Summary:Three new tryptamine derivatives diaporols T-V (1-3) were isolated by adding tryptamine into the culture of Diaporthe sp., a fungus obtained from the leaves of Rhizophora stylosa. The structures of these compounds were elucidated by NMR spectroscopy and high resolution mass spectroscopic data. Among them, compound 1 showed moderate cytotoxic activity against SW480 cancer cell with IC 50 9.84 μM.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2020.1866560