Two new compounds from Verbena bonariensis

Two new compounds verboncin A (1) and verboncin B (4) and 14 known compounds (2-3 and 5-16) were isolated from Verbena bonariensis, and these 14 compounds were first obtained from this plant. Their chemical structures were established by one and two-dimensional NMR and HRESIMS analysis and the resul...

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Bibliographic Details
Published in:Journal of asian natural products research 2023-07, Vol.25 (7), p.658-666
Main Authors: Li, Rui, Chen, Yuan-Si, Bi, De-Wen, Wei, Qiong, Zhou, Ya-Ling, Qiu, Xiong, Zhang, Rui-Han, Zhang, Xing-Jie, Xiao, Wei-Lie, Li, Hong-Liang, Li, Xiao-Li
Format: Article
Language:English
Subjects:
Absolute configuration
Circular dichroism
Cytotoxicity
Dichroism
iridoid
NMR
Nuclear magnetic resonance
sterol
Toxicity
Tumor cell lines
Two dimensional analysis
Verbena bonariensis
Verbenaceae
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Summary:Two new compounds verboncin A (1) and verboncin B (4) and 14 known compounds (2-3 and 5-16) were isolated from Verbena bonariensis, and these 14 compounds were first obtained from this plant. Their chemical structures were established by one and two-dimensional NMR and HRESIMS analysis and the results were compared with literature values. The absolute configuration of 1 was determined by calculating electronic circular dichroism (ECD). The cytotoxicity of some of the compounds against MCF-7, HCT-116, MDA-MB-231, and SW620 human cancer cell lines were evaluated, in which compound 4 showed negligible cytotoxic activity with an IC 50 value of 68.08 ± 0.35 µM against the MCF-7 cell line.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2022.2131550