Two unusual novel iridoid glycosides from Cornus officinalis fruit and their biological activities

Two unusual novel iridoid glycosides, cornsecoside A (1) and cornsecoside B (2), were isolated from a 40% ethanol elution fraction of a 50% ethanol extract of Cornus officinalis fruit. Their structures were determined by spectroscopic data analysis combined with hydrolysis and ECD spectroscopy. In a...

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Bibliographic Details
Published in:Journal of asian natural products research 2023-09, Vol.25 (9), p.860-866
Main Authors: Li, Bin, Wang, Xin, Lin, Peng-Cheng, Li, Jin-Jie, Luan, Na, Wang, Yun-Qin, Shang, Xiao-Ya
Format: Article
Language:English
Subjects:
bioactivities
Cornaceae
Cornus officinalis
Cytotoxicity
Data analysis
Ethanol
Fruits
Glycosides
Hydrogen peroxide
Neuroprotection
secoiridoid glycosides
Spectroscopy
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Summary:Two unusual novel iridoid glycosides, cornsecoside A (1) and cornsecoside B (2), were isolated from a 40% ethanol elution fraction of a 50% ethanol extract of Cornus officinalis fruit. Their structures were determined by spectroscopic data analysis combined with hydrolysis and ECD spectroscopy. In addition, compounds 1 and 2 exhibited cytotoxic activity against Bel-7402 cells with IC 50 values of 8.12 and 9.31 µM, and were neuroprotective against H 2 O 2 -induced SH-SY5Y cell injure at a concentration of 10 µM.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2022.2156341