Asterosaponins from the starfish Protoreaster nodosus

Five asterosaponins (1-5), including one new compound named protonodososide (1), were isolated from the methanol extract of the starfish Protoreaster nodosus, after subjecting to various chromatographic separations. The structural elucidation was confirmed by careful analysis of the 1D, 2D NMR, and...

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Bibliographic Details
Published in:Journal of asian natural products research 2023-12, Vol.25 (12), p.1229-1235
Main Authors: Vien, Le Thi, Hanh, Tran Thi Hong, Quang, Tran Hong, Thanh, Nguyen Van, Cuong, Nguyen Xuan, Nam, Nguyen Hoai, Do Cong, Thung, Kiem, Phan Van
Format: Article
Language:English
Subjects:
Asteroidea
asterosaponins
cytotoxic activity
Cytotoxicity
Mass spectra
NMR
Nuclear magnetic resonance
protonodososide
Protoreaster
Protoreaster nodosus
Tumor cell lines
Two dimensional analysis
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Summary:Five asterosaponins (1-5), including one new compound named protonodososide (1), were isolated from the methanol extract of the starfish Protoreaster nodosus, after subjecting to various chromatographic separations. The structural elucidation was confirmed by careful analysis of the 1D, 2D NMR, and HR ESI QTOF mass spectra. The cytotoxicity of isolated compounds was evaluated on five human cancer cell lines including HepG2, KB, MCF7, LNCaP, and SK-Mel2.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2023.2219616