New aporphine alkaloids with antitumor activities from the roots of Thalictrum omeiense

Two new aporphine alkaloids, 6a -2'-(3-oxobutenyl)-thaliadin ( ) and -methylthalisopynine ( ), along with ten known analogs ( - ), were isolated from the roots of W. T. Wang et S. H. Wang. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compounds...

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Bibliographic Details
Published in:Journal of asian natural products research 2024-02, p.1-9
Main Authors: Chen, Zhao-Jing, Yang, Han-Gao, Zhu, Wen-Peng, Xue, Chun-Mei, Zhang, Hong-Mei, Peng, Yu-Ting, Li, Da-Hong, Hua, Hui-Ming
Format: Article
Language:English
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Summary:Two new aporphine alkaloids, 6a -2'-(3-oxobutenyl)-thaliadin ( ) and -methylthalisopynine ( ), along with ten known analogs ( - ), were isolated from the roots of W. T. Wang et S. H. Wang. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compounds - and - were tested for their antiproliferative effects against two human cancer cell lines (A549 and MCF-7). Among them, compounds , and exhibited moderate inhibitory activity against the tested cell lines with IC values ranging from 23.73 to 34.97 μM.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2024.2317826