Green Synthesis and Anticancer Evaluation of Novel Chrysin Hydrazone Derivatives

Chrysin, a natural flavonoid, has been investigated for its anticancer biological properties. Antifungal and anticancer properties of hydrazone derivatives have been proven. In this study, eight compounds of substituted Chrysin hydrazine derivatives have been designed, synthesized, and screened agai...

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Bibliographic Details
Published in:Polycyclic aromatic compounds 2023-01, Vol.43 (1), p.176-189
Main Authors: Pouramiri, Behjat, Seyedhosseini, Seyed Reza, Nematollahi, Mohammad Hadi, Faramarz, Sanaz, Seyedi, Fatemeh, Ayati, Adileh
Format: Article
Language:English
Subjects:
anticancer activity
Anticancer properties
Antiproliferatives
Antitumor agents
Apoptosis
Biological properties
Cancer
Chemical compounds
Chemical synthesis
Chrysin
Cytotoxicity
Drug development
flavonoid
Flavonoids
Fungicides
Hydrazine
Hydrazines
Hydrazones
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Summary:Chrysin, a natural flavonoid, has been investigated for its anticancer biological properties. Antifungal and anticancer properties of hydrazone derivatives have been proven. In this study, eight compounds of substituted Chrysin hydrazine derivatives have been designed, synthesized, and screened against cancerous cell lines, including MCF-7 and HepG-2. All products are reported for the first time. Most compounds exhibited significant cytotoxic activity against selected cell lines. The chemical structures of all compounds were confirmed by spectroscopic methods and elemental analyzes. In vitro evaluation of these synthesized compounds showed most of them have potential antiproliferative activity. Compounds 3e and 3f have shown significant anti-proliferative activity against MCF-7 and HepG-2 cell lines, respectively, compared to Chrysin (P 
ISSN:1040-6638
1563-5333
DOI:10.1080/10406638.2021.2011753