Multi-step Synthesis of Novel Pyrazole Derivatives as Anticancer Agents

The attractiveness of pyrazole and its derivatives is increasing because of their numerous potential pharmacological applications. A novel series of pyrazole hybrid compounds (6A-6L) has been synthesized, and all the intermediates and the final products were characterized by 1H NMR, IR, and mass spe...

Full description

Saved in:
Bibliographic Details
Published in:Polycyclic aromatic compounds 2024-11, Vol.44 (10), p.6550-6563
Main Authors: Vyas, Amita K., Lunagariya, Kaushik S., Khunt, Ranjan C.
Format: Article
Language:English
Subjects:
Anticancer properties
anticancer screening
Antineoplastic drugs
Antitumor activity
Intermediates
Leukemia
Mass spectrometry
Mass spectroscopy
Melanoma
NCI-60 cell line
NMR
Nuclear magnetic resonance
Ovarian cancer
Pyrazole
Pyrazoles
spectroscopy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The attractiveness of pyrazole and its derivatives is increasing because of their numerous potential pharmacological applications. A novel series of pyrazole hybrid compounds (6A-6L) has been synthesized, and all the intermediates and the final products were characterized by 1H NMR, IR, and mass spectrometry. Pyrazole derivatives were screened for their anticancer activity against the NCI-60 cell lines, and grouped into nine different subpanels. In-vitro anticancer studies of the targeted compounds showed that the compounds 6C, 6D, 6F, 6I, and 6J showed potent anticancer activity against renal cancer, ovarian cancer, melanoma, and leukemia cancer.
ISSN:1040-6638
1563-5333
DOI:10.1080/10406638.2023.2278664