Molecularly imprinted polymers as receptors for assays of antibiotics

The use of excessive antibiotics in medical treatment and animal breeding has led to their prevalence in the environment and foods. Thereby, rapid, cheap, and sustainable techniques are required to detect and control the potential risk related to antibiotics. Actually, immunoassays have wide applica...

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Bibliographic Details
Published in:Critical reviews in analytical chemistry 2020-07, Vol.50 (4), p.291-310
Main Authors: Tarannum, Nazia, Hendrickson, Olga D., Khatoon, Shahjadi, Zherdev, Anatoly V., Dzantiev, Boris B.
Format: Article
Language:English
Subjects:
Animal breeding
Animals
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - chemistry
Antibiotics
Antibodies
artificial antibodies
detection
Fluorescence
Fluorescent indicators
food safety control
Humans
Immunoassay
Immunoassays
Imprinted polymers
Medical treatment
Molecular imprinting
molecularly imprinted polymers
Molecularly Imprinted Polymers - chemical synthesis
Molecularly Imprinted Polymers - chemistry
Polymers
Receptors
Risk management
Tracers
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Summary:The use of excessive antibiotics in medical treatment and animal breeding has led to their prevalence in the environment and foods. Thereby, rapid, cheap, and sustainable techniques are required to detect and control the potential risk related to antibiotics. Actually, immunoassays have wide applications for this purpose, and improved assay formats with enzymatic, fluorescent, nanodispersed, and other tracers have enhanced the efficiency of the technique. However, there are several shortcomings of immunoassay due to the protein nature of antibodies. Thereby, molecular imprinting technology has evolved as growing artificial analytical receptor for molecular recognition with binding properties similar to natural antibodies. Molecularly imprinted polymers (MIPs) are defined as "plastibodies" or substitutes for antibodies in immunoassays. This review gives a general overview of the application of molecular imprinting to analytical systems, its state of art, and perspective. The application of MIP-based assays in the detection of antibiotics in food and environmental samples is explored herein.
ISSN:1040-8347
1547-6510
DOI:10.1080/10408347.2019.1626697