Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective

Impairment of the epithelial barrier function is closely linked to the pathogenesis of various gastrointestinal diseases, food allergies, type I diabetes, and other systematic diseases. Plant-derived polyphenols are natural secondary metabolites and exert various physiological benefits, including an...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2017-12, Vol.57 (18), p.3830-3839
Main Authors: Yang, Guan, Bibi, Shima, Du, Min, Suzuki, Takuya, Zhu, Mei-Jun
Format: Article
Language:English
Subjects:
Aging (natural)
Allergies
Anti-Inflammatory Agents - pharmacology
barrier function
Carcinogens
Diabetes mellitus
Diseases
Food allergies
Food plants
Functional foods & nutraceuticals
Gastrointestinal diseases
Hogs
Humans
Inflammatory diseases
Intestinal Diseases - prevention & control
intestinal epithelium
Intestinal Mucosa
Intestine
Intestines
Metabolites
Pathogenesis
Physiological effects
Plant diseases
Plants
Polyphenols
Polyphenols - pharmacology
Secondary metabolites
signaling pathway
Small intestine
tight junction
Tight Junctions - drug effects
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Summary:Impairment of the epithelial barrier function is closely linked to the pathogenesis of various gastrointestinal diseases, food allergies, type I diabetes, and other systematic diseases. Plant-derived polyphenols are natural secondary metabolites and exert various physiological benefits, including anti-inflammatory, anti-oxidative, anti-carcinogenic, and anti-aging effects. Recent studies also show the role of plant polyphenols in regulation of the intestinal barrier and prevention of intestinal inflammatory diseases. Here we summarize the regulatory pathways and mediators linking polyphenols to their beneficial effects on tight junction and gut epithelial barrier functions, and provide useful information about using polyphenols as nutraceuticals for intestinal diseases.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2016.1152230