A novel bioactive postbiotics: from microbiota-derived extracellular nanoparticles to health promoting

In recent years, the emerging concern regarding safety issues associated with live bacterial cells is enhancing the interest in using cell components and metabolites derived from microbiota. Therefore, the term "postbiotics" is increasingly found in food microbiology, food scientific and c...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2023-09, Vol.63 (24), p.6885-6899
Main Authors: Gu, Zelin, Meng, Shuhan, Wang, Yu, Lyu, Bo, Li, Pinglan, Shang, Nan
Format: Article
Language:English
Subjects:
Biological activity
biomedical function
Biomedical materials
Digestive system
Food
Food microbiology
functional food
Functional foods & nutraceuticals
Functionals
Gastrointestinal tract
health promoting
Health promotion
Intestinal microflora
Metabolites
Microbiology
Microbiome
Microbiota
microbiota-derived nanoparticles
Microorganisms
Nanoparticles
postbiotics
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Summary:In recent years, the emerging concern regarding safety issues associated with live bacterial cells is enhancing the interest in using cell components and metabolites derived from microbiota. Therefore, the term "postbiotics" is increasingly found in food microbiology, food scientific and commercial products. Postbiotics is defined as non-viable microorganisms or their components that provide benefits to the host. Many in vivo and in vitro experiments have shown that beneficial microbiota-generated extracellular nanoparticles (NPs) confer unique health promoting functions to the intestinal local and systemic effects, which can be considered as a novel postbiotics. Meanwhile, the postbiotics-NPs is a protective complex, delivering bioactive components to reach distant tissues and organs at high concentrations. These properties demonstrate that postbiotics-NPs may contribute to the improvement of host health by regulating specific gut microbiota and physiological functions, while the exact mechanisms are not fully elucidated. This review highlights the current understanding of postbiotics-NPs functional properties and mechanisms of health benefits, especially focusing on the interactions in gut microbiota and host, functions in human health and potential applications in future functional food and biomedical fields.
ISSN:1040-8398
1549-7852
1549-7852
DOI:10.1080/10408398.2022.2039897