Convenient Synthesis of Some Thiadiazolotriazinones Carrying 4-Methylthiobenzyl Moieties as Possible Antimicrobial Agents

4-amino-6-(4-methylthiobenzyl)-3-mercapto-1,2,4-triazin-5(4H)-one was condensed with various substituted benzoic acids/aryloxyacetic acids in the presence of phosphorus oxychloride to afford a series of 7-(substituted aryl/aryloxymethyl)-3-(4-methylthiobenzyl)-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-triaz...

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Bibliographic Details
Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2007-05, Vol.182 (5), p.981-991
Main Authors: Ashok, Mithun, Holla, B. Shivarama
Format: Article
Language:English
Subjects:
1,2,4-triazin-5(4H)-one
1,3,4-Thiadiazole
antibacterial
antifungal
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Summary:4-amino-6-(4-methylthiobenzyl)-3-mercapto-1,2,4-triazin-5(4H)-one was condensed with various substituted benzoic acids/aryloxyacetic acids in the presence of phosphorus oxychloride to afford a series of 7-(substituted aryl/aryloxymethyl)-3-(4-methylthiobenzyl)-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-ones in good yields. The structures of the newly synthesized compounds were confirmed on the basis of elemental analysis, IR, 1 H NMR, and mass spectral studies. All the newly synthesized compounds were tested for their antibacterial and antifungal activity against a variety of microorganisms.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426500601088853