Environmentally Friendly Preparation of 3,4-Dihydropyrimidin-2(1H)-thiones Catalyzed by Al(H2PO4)3

An efficient, facile, simple, and green synthetic protocol for the Biginelli reaction has been developed for the preparation of 3,4-dihydropyrimidin-2(1H)-thione derivatives under thermal and microwave irradiation, solvent-free conditions, in the presence of aluminum hydrogen phosphate, Al(H 2 PO 4...

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Bibliographic Details
Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2009-01, Vol.184 (1), p.126-134
Main Authors: Shaterian, Hamid Reza, Hosseinian, Asghar, Ghashang, Majid
Format: Article
Language:English
Subjects:
3,4-dihydropyrimidin-2(1H)-thione
Al(H
Biginelli reaction
heterogeneous catalyst
multicomponent reaction
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Summary:An efficient, facile, simple, and green synthetic protocol for the Biginelli reaction has been developed for the preparation of 3,4-dihydropyrimidin-2(1H)-thione derivatives under thermal and microwave irradiation, solvent-free conditions, in the presence of aluminum hydrogen phosphate, Al(H 2 PO 4 ) 3 , as an environmentally friendly heterogeneous recyclable catalyst, in high to excellent yields and short reaction time. In addition, the catalyst could be easily recovered from the reaction mixture by simple filtration and reused several times without any loss of activity.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426500802080576