Synthesis of Novel N,N-Disubstituted Ethyl P-[2-(1H-Indol-3-YL)Acetyl]Phosphoramidates and Their Biological Activity

A series of novel N,N-disubstituted ethyl P-[2-(1H-indol-3-yl)acetyl]phosphoramid-ates were synthesized. All title compounds were characterized by IR, NMR ( 1 H, 13 C, 31 P) spectra, mass spectra, and C, H, N analysis. The anticancer activity of the title compounds was evaluated in two human cell li...

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Bibliographic Details
Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2015-11, Vol.190 (11), p.2013-2022
Main Authors: Venkata Ramana, K., Madhava, G., Ravendra Babu, K., Subbarao, D., Hema Kumar, K., Naga Raju, C.
Format: Article
Language:English
Subjects:
Biological activity
Breast cancer
Cytotoxicity
HeLa cell lines
Indole-3-acetic acid (IAA)
ketophosponates
MCF-7 cell lines
MTT assay
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Summary:A series of novel N,N-disubstituted ethyl P-[2-(1H-indol-3-yl)acetyl]phosphoramid-ates were synthesized. All title compounds were characterized by IR, NMR ( 1 H, 13 C, 31 P) spectra, mass spectra, and C, H, N analysis. The anticancer activity of the title compounds was evaluated in two human cell lines MCF-7 (breast cancer) and HeLa (Cervical cancer) cell lines by the use of the MTT assay, and the IC 50 values were determined. The derivatives with substituted piperazines exhibited significant cytotoxicity against the tested cell lines at 5 μM and displayed low IC 50 values in the region of 5.8-8.8 μM for MCF-7 cell lines and 14.8-16.4 μM for HeLa cell lines when compared with the standard doxorubicin (5.4 and 14.2 μM).
ISSN:1042-6507
1563-5325
DOI:10.1080/10426507.2015.1054930