Hypoglycaemia and Lactic Acidosis in a MALT Non Hodgkin's Lymphoma

Hypoglycaemia associated with lactic acidosis is a rare complication of lymphomas; only four cases have been previously reported. Recent studies provide evidence of direct consumption of glucose by the tumour cells, leading to lactic acidosis. We report the case of a 64-year-old patient with a gastr...

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Bibliographic Details
Published in:Leukemia & lymphoma 2002, Vol.43 (6), p.1341-1342
Main Authors: Di Comite, Gabriele, Dagna, Lorenzo, Piatti, Piero M., Monti, Lucilla D., Tantardini, Francesca, Praderio, Luisa
Format: Article
Language:English
Subjects:
Acidosis
Acidosis, Lactic - etiology
Acute Kidney Injury - etiology
Fatal Outcome
Female
Humans
Hypoglycaemia
Hypoglycemia - etiology
Lactic acidosis
Lymphoma, B-Cell, Marginal Zone - complications
Lymphoma, B-Cell, Marginal Zone - metabolism
Middle Aged
Mucosa associated lymphoid tissue (MALT) lymphoma
Non-Hodgkin's lymphoma
Stomach Neoplasms - complications
Stomach Neoplasms - metabolism
Tumor Lysis Syndrome - complications
Tumour lysis syndrome
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Summary:Hypoglycaemia associated with lactic acidosis is a rare complication of lymphomas; only four cases have been previously reported. Recent studies provide evidence of direct consumption of glucose by the tumour cells, leading to lactic acidosis. We report the case of a 64-year-old patient with a gastric diffuse large B cell non-Hodgkin's lymphoma transformed from an indolent mucosa associated lymphoid tissue (MALT) lymphoma, admitted to our department for acute renal failure due to a tumour lysis syndrome. After recovery from renal failure, she developed severe hypoglycaemia and lactic acidosis refractory to therapy. She died after the onset of shock and coma.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428190290026420