FDG PET-CT evaluation in neurolymphomatosis: imaging characteristics and clinical outcomes

Neurolymphomatosis (NL) often represents unidentified non-Hodgkin lymphoma relapses. Considering its severity, early detection and treatment are crucial. We outline one hospital's 18 F-FDG-PET-CT imaging findings of NL, along with the patients' clinical characteristics. Clinical records an...

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Bibliographic Details
Published in:Leukemia & lymphoma 2018-02, Vol.59 (2), p.348-356
Main Authors: Davidson, Tima, Kedmi, Meirav, Avigdor, Abraham, Komisar, Orna, Chikman, Bar, Lidar, Merav, Goshen, Elinor, Tzila Zwas, S., Ben-Haim, Simona
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Animals
FDG PET-CT
Female
Fluorodeoxyglucose F18
Follow-Up Studies
Humans
Image Interpretation, Computer-Assisted
Image Processing, Computer-Assisted
lymphoma
Male
Marek Disease - diagnostic imaging
Marek Disease - mortality
Marek Disease - pathology
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
neurolymphomatosis
Positron Emission Tomography Computed Tomography - methods
Prognosis
Retrospective Studies
Young Adult
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Summary:Neurolymphomatosis (NL) often represents unidentified non-Hodgkin lymphoma relapses. Considering its severity, early detection and treatment are crucial. We outline one hospital's 18 F-FDG-PET-CT imaging findings of NL, along with the patients' clinical characteristics. Clinical records and imaging findings of 19 NL patients, PET-CT diagnosed, were retrospectively reviewed. Patient data, FDG-PET-CT findings and the presence of coexisting diseases, especially CNS involvement, were documented. Available MRI and clinical data verified the findings. All cases had increased linear FDG uptake along anatomic nerve sites. CTs showed varying degrees of corresponding soft-tissue-thickening. Clinical correlations also contributed to the diagnosis. In 4/19 patients, lymphoma presented with NL, in 15/19 it appeared with disease recurrence/progression. In 9/19, clinical symptoms suggested neural involvement while 10/19 had nonspecific symptoms. Eleven died of lymphoma within 0.9 years of diagnosis despite directed-therapy. Eight, however, survived up to 7.82 years post-diagnosis. Whole-body FDG-PET-CT can assist in early NL diagnosis, possibly enhancing survival.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428194.2017.1352096