SOX11 inhibits tumor proliferation and promotes cell adhesion mediated-drug resistance via a CD43 dependent manner in mantle cell lymphoma

• Published in: Leukemia & lymphoma 2020-07, Vol.61 (9), p.2068-2081
• Main Authors: Yang, Rumeng, Huo, Zitian, Duan, Yaqi, Tong, Weilin, Zheng, Yiyun, Su, Yinxia, Lou, Liping, Zhang, Qian, Xu, Sanpeng, Peng, Changqing, Kuang, Dong, Wang, Guoping
• Format: Article
• Language: English
• Subjects: Adult; CD43; Cell Adhesion; cell adhesion mediated-drug resistance; Cell Proliferation; Drug Resistance; Humans; Lymphoma, Mantle-Cell - genetics; Mantle cell lymphoma; proliferation; SOX11; SOXC Transcription Factors - genetics
• ISSN: 1042-8194; 1029-2403
• DOI: 10.1080/10428194.2020.1762877

SOX11 is a critical biomarker for mantle cell lymphoma (MCL) diagnosis; however, its role remains unclear in MCL. Here, clinical-pathological analysis showed Ki67 index was negatively relevant to SOX11 expression only in CD43 positive cases. Coexpression of SOX11/CD43 indicated longer overall survival. In vitro, knockout/overexpression of SOX11 or CD43 promoted/inhibited cell proliferation respectively. CD43 overexpression reversed tumor proliferation induced by SOX11 knockdown. Furthermore, overexpressing/silencing the SOX11/CD43 gene affects phosphorylation of p38-MAPK while p38 inhibitor reversed proliferation induced by si-SOX11 or si-CD43, respectively. In CAM-DR model, both SOX11 and CD43 in MCL cells were elevated when co-cultured with M2-10B4 bone marrow fibroblasts or fibronectin. Knockdown/overexpression of SOX11 decreased/increased cell adhesion, respectively, and the effect induced by silencing SOX11 was reversed by overexpression of CD43. Collectively, SOX11 could inhibit tumor proliferation and promote CAM-DR in a CD43 dependent manner.