Validation and reference values of the EORTC QLQ-CML24 questionnaire to assess health-related quality of life in patients with chronic myeloid leukemia

Health-related quality of life (HRQOL) assessment is important to facilitate decisions in the current treatment landscape of chronic myeloid leukemia (CML). Therefore, the availability of a validated HRQOL questionnaire, specifically developed for CML patients treated with tyrosine kinase inhibitors...

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Bibliographic Details
Published in:Leukemia & lymphoma 2021-02, Vol.62 (3), p.669-678
Main Authors: Efficace, Fabio, Iurlo, Alessandra, Patriarca, Andrea, Stagno, Fabio, Bee, Ping-Chong, Ector, Geneviève, Capodanno, Isabella, Elena, Chiara, Bonifacio, Massimiliano, Blijlevens, Nicole M. A., Caocci, Giovanni, Wan, Chonghua, Abruzzese, Elisabetta, Breccia, Massimo, Cottone, Francesco, Okumura, Iris, Oerlemans, Simone, Cascavilla, Nicola, Albano, Francesco, Kota, Vamsi, Sztankay, Monika, Miggiano, Maria Cristina, Saussele, Susanne, Di Renzo, Nicola, Sorà, Federica, Castagnetti, Fausto, Baccarani, Michele, Vignetti, Marco, Rosti, Gianantonio
Format: Article
Language:English
Subjects:
chronic myeloid leukemia
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy
patient-reported outcomes
Quality of Life
Reference Values
Reproducibility of Results
Surveys and Questionnaires
symptoms
tyrosine kinase inhibitors
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Summary:Health-related quality of life (HRQOL) assessment is important to facilitate decisions in the current treatment landscape of chronic myeloid leukemia (CML). Therefore, the availability of a validated HRQOL questionnaire, specifically developed for CML patients treated with tyrosine kinase inhibitors (TKIs), may enhance quality of research in this area. We performed an international study including 782 CML patients to assess the validity of the EORTC QLQ-CML 24 questionnaire, and to generate HRQOL reference values to facilitate interpretation of results in future studies. Internal consistency, assessed with Cronbach's alpha coefficients, ranged from 0.66 to 0.83. In the confirmatory factor analysis, all standardized factor loadings exceeded the threshold of 0.40 (range 0.49-0.97), confirming the hypothesized scale structure. Reference values stratified by age and sex were also generated. Our findings support the use of the EORTC QLQ-CML 24, in conjunction with the EORTC QLQ-C30, as a valuable measure to assess HRQOL in CML patients.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428194.2020.1838509