Systematic review reveals urgent need to homogenize endpoints choices and definitions in marginal zone lymphomas trials

• Published in: Leukemia & lymphoma 2022-06, Vol.63 (7), p.1544-1555
• Main Authors: Bommier, Côme, Ruggiu, Mathilde, Monégier, Aymeric, Zucca, Emanuele, Thieblemont, Catherine, Lambert, Jérôme
• Format: Article
• Language: English
• Subjects: definitions; endpoints; indolent lymphoma; Marginal zone lymphoma; systematic review
• ISSN: 1042-8194; 1029-2403
• DOI: 10.1080/10428194.2022.2032038

Marginal zone lymphoma (MZL) is a heterogeneous disease and has various end-point measures. Our aim was to describe the endpoints used in trials involving patients with MZL. We searched over the last 35 years via PubMed, The Cochrane Library, clinicaltrials.govandclinicaltrialsregister.eu for published and registered clinical trials using the keyword "marginalzone lymphoma." We excluded studies focusing on pediatric populations, cutaneous MZL and on use of allogenic stem cell transplant. Endpoints were reviewed as well as their influencing factors and their definitions. Among 1192 references Q7 dentified by initial screening, 309 references were included (111 published, 198 registered), with 213 (69%) phase 2, 65 (21%) phase 1/2 and 31 (10%) phase 3 trials. The majority were open-label (n¼295, 95%) non-randomized (n¼256, 83%) trials, concerned all subtypes of MZLs at once (n¼239, 77%), and were often merged with non-MZL patients (n¼232, 75%). Among phase 1/2 and 2 trials, Overall/complete response rate (ORR/CRR) (n¼196, 70.5%) and progression-free survival (PFS,n¼28, 10.1%) were the most used primary endpoints; in phase 3 trials PFS was the most used primary endpoint (n¼18, 58.1%; ORR/CRR n¼6, 19.4%, p