Nesfatin-1 and neuronostatin neurons are co-expressed with glucocorticoid receptors in the hypothalamus

Nesfatin-1 and neuronostatin in the central nervous system participate in regulating stress responses. Glucocorticoid hormones affect the brain through glucocorticoid receptors (GR). We investigated in the rat the possibility of co-localizing nesfatin-1 and neuronostatin neurons in hypothalamic area...

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Bibliographic Details
Published in:Biotechnic & histochemistry 2021-10, Vol.96 (7), p.555-561
Main Authors: Ekizceli, G, Halk, KZ, Minbay, Z, Eyigor, O
Format: Article
Language:English
Subjects:
Animals
Calcium-Binding Proteins - metabolism
DNA-Binding Proteins - metabolism
Female
Glucocorticoid
hypothalamus
Hypothalamus - metabolism
Male
Nerve Tissue Proteins - metabolism
nesfatin-1
neuronostatin
Neurons - metabolism
Nucleobindins
Peptide Fragments
rat
Rats
receptors
Receptors, Glucocorticoid
Somatostatin
stress
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Summary:Nesfatin-1 and neuronostatin in the central nervous system participate in regulating stress responses. Glucocorticoid hormones affect the brain through glucocorticoid receptors (GR). We investigated in the rat the possibility of co-localizing nesfatin-1 and neuronostatin neurons in hypothalamic areas with GR. using immunohistochemistry. We counted nesfatin-1 and neuronostatin stained neurons. We counted GR positive nesfatin-1 neurons in the arcuate nucleus (ARC) and paraventricular nucleus (PVN) and GR positive neuronostatin neurons in the periventricular nucleus (PeN). The percentage of nesfatin-1 neurons that expressed GR was 38.4% in female rats and 21.9% in male rats in the ARC, and 33.3% in female rats and 29.2% in male rats in the PVN. The percentage of neuronostatin neurons that expressed GR was 39.1% in female rats and 39.9% in male rats in the PeN. We found that a substantial portion of nesfatin-1 and neuronostatin neurons were stained for GR. We speculate that the pattern of GR might permit secretion of neuropeptides to be stimulated by peripheral glucocorticoid signals. Stress can suppress food intake, in part, through the GR in neurons that express nesfatin-1, which is a satiety molecule, and in neurons that express neuronostatin, which is an anorexigenic peptide.
ISSN:1052-0295
1473-7760
DOI:10.1080/10520295.2020.1832703