Preparation of Biomimetic Zwitterionic Core Cross-Linked Nanocarriers for Control Release of Bioactive Agents

Biomimetic core cross-linked nanocarriers (CCL-NCs) with zwitterionic shell was constructed from an amphiphilic block copolymer poly(2-(dimethylamino) ethyl methacrylate-co-carboxybetaine)-b-polystyrene ((PDMAEMA-co-PCB)-b-PS) via mini-emulsion RAFT polymerization. CCL-NCs present in this report pos...

Full description

Saved in:
Bibliographic Details
Published in:Journal of macromolecular science. Part A, Pure and applied chemistry Pure and applied chemistry, 2013-01, Vol.50 (6), p.644-652
Main Authors: Wang, Xiaohong, Jiang, Guohua, Wang, Yin, Wang, Rijing, Sun, Xinke, Hu, Ruanbing, Xi, Xiaoguang, Zhou, Yang, Wang, Sheng, Wang, Tao
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Biomimetic
controlled release
core cross-linked nanocarriers
Crosslinking
drug delivery
Exact sciences and technology
General pharmacology
Medical sciences
Nanocomposites
Nanomaterials
Nanostructure
Organic polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Polymers with particular properties
Preparation, kinetics, thermodynamics, mechanism and catalysts
Protein adsorption
Rafts
Shells
Transmission electron microscopy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Biomimetic core cross-linked nanocarriers (CCL-NCs) with zwitterionic shell was constructed from an amphiphilic block copolymer poly(2-(dimethylamino) ethyl methacrylate-co-carboxybetaine)-b-polystyrene ((PDMAEMA-co-PCB)-b-PS) via mini-emulsion RAFT polymerization. CCL-NCs present in this report possess properties of redox-sensitivity, limited unspecific protein adsorptions and low cytotoxicity, which highly enhance their potential application in drug delivery. Morphology of CCL-NCs was characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements. The control release process has also been investigated under three different conditions with or without dithiothreitol (DTT) at pH 5.4, 6.5 and 7.4.
ISSN:1060-1325
1520-5738
DOI:10.1080/10601325.2013.784569