Overcoming the Inflammatory Toxicity of Cationic Gene Vectors

Cationic lipid- and polymer-based vectors are the most extensively studied synthetic gene vectors. These vectors have been widely used in animal models and some have been tested in clinical trials. The clinical progress of these vectors has been slowed by their inflammatory toxicity. This review sum...

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Bibliographic Details
Published in:Journal of drug targeting 2002-03, Vol.10 (2), p.153-160
Main Authors: Tan, Yadi, Huang, Leaf
Format: Article
Language:English
Subjects:
Administration, Inhalation
Animals
Cationic Gene Vector
Cationic Liposome
Cationic Polymer
Cations - toxicity
Cpg Motif
Genetic Therapy - adverse effects
Genetic Vectors - toxicity
Humans
Inflammation - chemically induced
Inflammation - prevention & control
Inflammatory Toxicity
Injections, Intraperitoneal
Injections, Intravenous
Intubation, Intratracheal
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Summary:Cationic lipid- and polymer-based vectors are the most extensively studied synthetic gene vectors. These vectors have been widely used in animal models and some have been tested in clinical trials. The clinical progress of these vectors has been slowed by their inflammatory toxicity. This review summarizes the observations, the mechanisms, and various strategies employed to overcome the inflammatory toxicity of cationic gene vectors.
ISSN:1061-186X
1029-2330
DOI:10.1080/10611860290016757