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Folate-receptor-targeted delivery of docetaxel nanoparticles prepared by PLGA-PEG-folate conjugate
For folate-receptor-targeted anticancer therapy, docetaxel (DTX) nanoparticles (NPs) were produced employing polylactide-co-glycolide-polyethylene glycol-folate (PLGA-PEG-FOL) conjugate. The FOL-conjugated di-block copolymer was synthesized by coupling the PLGA-PEG-NH2 di-block copolymer with an act...
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| Published in: | Journal of drug targeting 2008-01, Vol.16 (5), p.415-423 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c465t-d804b3440fc785a40ca2e62c282731baec75e87487057fd59d63e75d3b2a15e83 |
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| cites | cdi_FETCH-LOGICAL-c465t-d804b3440fc785a40ca2e62c282731baec75e87487057fd59d63e75d3b2a15e83 |
| container_end_page | 423 |
| container_issue | 5 |
| container_start_page | 415 |
| container_title | Journal of drug targeting |
| container_volume | 16 |
| creator | Esmaeili, Farnaz Ghahremani, Mohammad Hossein Ostad, Seyed Nasser Atyabi, Fatemeh Seyedabadi, Mohammad Malekshahi, Mazda Rad Amini, Mohsen Dinarvand, Rassoul |
| description | For folate-receptor-targeted anticancer therapy, docetaxel (DTX) nanoparticles (NPs) were produced employing polylactide-co-glycolide-polyethylene glycol-folate (PLGA-PEG-FOL) conjugate. The FOL-conjugated di-block copolymer was synthesized by coupling the PLGA-PEG-NH2 di-block copolymer with an activated folic acid. It was expected that FOL moieties were exposed on the micellar surface.
The conjugates assisted in the formation of DTX NPs with an average size of 200 nm in diameter through an emulsification/solvent diffusion method. The FOL-targeted NPs showed a greater extent of intracellular uptake in FOL-receptor-positive cancer cells (SKOV3) in comparison with the non-targeted NPs, indicating that the FOL-receptor-mediated endocytosis mechanism could have a role in the cellular uptake of NPs. These results suggested that FOL-targeted DTX NPs could be a potentially useful delivery system for FOL-receptor-positive cancer cells. |
| doi_str_mv | 10.1080/10611860802088630 |
| format | article |
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The conjugates assisted in the formation of DTX NPs with an average size of 200 nm in diameter through an emulsification/solvent diffusion method. The FOL-targeted NPs showed a greater extent of intracellular uptake in FOL-receptor-positive cancer cells (SKOV3) in comparison with the non-targeted NPs, indicating that the FOL-receptor-mediated endocytosis mechanism could have a role in the cellular uptake of NPs. These results suggested that FOL-targeted DTX NPs could be a potentially useful delivery system for FOL-receptor-positive cancer cells.</description><identifier>ISSN: 1061-186X</identifier><identifier>EISSN: 1029-2330</identifier><identifier>DOI: 10.1080/10611860802088630</identifier><identifier>PMID: 18569286</identifier><language>eng</language><publisher>Abington: Informa UK Ltd</publisher><subject>Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - pharmacokinetics ; Antineoplastic Agents - pharmacology ; Biological and medical sciences ; Carrier Proteins - metabolism ; Cell Line, Tumor ; Cell Survival - drug effects ; Chromatography, High Pressure Liquid ; docetaxel ; Drug Carriers ; Endocytosis - physiology ; Excipients ; Folate ; Folate Receptors, GPI-Anchored ; Folic Acid - chemistry ; General pharmacology ; Humans ; Lactic Acid - chemistry ; Medical sciences ; nanoparticle ; Nanoparticles ; nanotechnology ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; PLGA ; Polyethylene Glycols - chemistry ; Polyglycolic Acid - chemistry ; Receptors, Cell Surface - metabolism ; targeted delivery ; Taxoids - administration & dosage ; Taxoids - pharmacokinetics ; Taxoids - pharmacology</subject><ispartof>Journal of drug targeting, 2008-01, Vol.16 (5), p.415-423</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-d804b3440fc785a40ca2e62c282731baec75e87487057fd59d63e75d3b2a15e83</citedby><cites>FETCH-LOGICAL-c465t-d804b3440fc785a40ca2e62c282731baec75e87487057fd59d63e75d3b2a15e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20418784$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18569286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Esmaeili, Farnaz</creatorcontrib><creatorcontrib>Ghahremani, Mohammad Hossein</creatorcontrib><creatorcontrib>Ostad, Seyed Nasser</creatorcontrib><creatorcontrib>Atyabi, Fatemeh</creatorcontrib><creatorcontrib>Seyedabadi, Mohammad</creatorcontrib><creatorcontrib>Malekshahi, Mazda Rad</creatorcontrib><creatorcontrib>Amini, Mohsen</creatorcontrib><creatorcontrib>Dinarvand, Rassoul</creatorcontrib><title>Folate-receptor-targeted delivery of docetaxel nanoparticles prepared by PLGA-PEG-folate conjugate</title><title>Journal of drug targeting</title><addtitle>J Drug Target</addtitle><description>For folate-receptor-targeted anticancer therapy, docetaxel (DTX) nanoparticles (NPs) were produced employing polylactide-co-glycolide-polyethylene glycol-folate (PLGA-PEG-FOL) conjugate. The FOL-conjugated di-block copolymer was synthesized by coupling the PLGA-PEG-NH2 di-block copolymer with an activated folic acid. It was expected that FOL moieties were exposed on the micellar surface.
The conjugates assisted in the formation of DTX NPs with an average size of 200 nm in diameter through an emulsification/solvent diffusion method. The FOL-targeted NPs showed a greater extent of intracellular uptake in FOL-receptor-positive cancer cells (SKOV3) in comparison with the non-targeted NPs, indicating that the FOL-receptor-mediated endocytosis mechanism could have a role in the cellular uptake of NPs. These results suggested that FOL-targeted DTX NPs could be a potentially useful delivery system for FOL-receptor-positive cancer cells.</description><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Chromatography, High Pressure Liquid</subject><subject>docetaxel</subject><subject>Drug Carriers</subject><subject>Endocytosis - physiology</subject><subject>Excipients</subject><subject>Folate</subject><subject>Folate Receptors, GPI-Anchored</subject><subject>Folic Acid - chemistry</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Lactic Acid - chemistry</subject><subject>Medical sciences</subject><subject>nanoparticle</subject><subject>Nanoparticles</subject><subject>nanotechnology</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>PLGA</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyglycolic Acid - chemistry</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>targeted delivery</subject><subject>Taxoids - administration & dosage</subject><subject>Taxoids - pharmacokinetics</subject><subject>Taxoids - pharmacology</subject><issn>1061-186X</issn><issn>1029-2330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkU9v1DAQxS1ERf_AB-CCcoGbYWwntldwqap2QVqpPRSJW-TYkzYrbxxsp7DfHre7gBBSe_Kz_HsznnmEvGbwnoGGDwwkY1oWyUFrKeAZOWLAF5QLAc_vtWS0AN8OyXFKawAmJIMX5JDpRi64lkekuwjeZKQRLU45RJpNvMGMrnLohzuM2yr0lQsWs_mJvhrNGCYT82A9pmqKWC4F7rbV1Wp5Sq_Ol7R_qFjZMK7nm6JekoPe-ISv9ucJ-Xpxfn32ma4ul1_OTlfU1rLJ1GmoO1HX0FulG1ODNRwlt1xzJVhn0KoGtaq1gkb1rlk4KVA1TnTcsPIiTsi7Xd0phu8zptxuhmTRezNimFNbJha6rOpJkIMqfdiigGwH2hhSiti3Uxw2Jm5bBu19Au1_CRTPm33xudug--vYr7wAb_eASdb4PprRDukPx6FmWum6cJ923DD2IW7MjxC9a7PZ-hB_m8Rj__j4j_0Wjc-3tqTVrsMcx5LEI1P8Ai8qstY</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Esmaeili, Farnaz</creator><creator>Ghahremani, Mohammad Hossein</creator><creator>Ostad, Seyed Nasser</creator><creator>Atyabi, Fatemeh</creator><creator>Seyedabadi, Mohammad</creator><creator>Malekshahi, Mazda Rad</creator><creator>Amini, Mohsen</creator><creator>Dinarvand, Rassoul</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Folate-receptor-targeted delivery of docetaxel nanoparticles prepared by PLGA-PEG-folate conjugate</title><author>Esmaeili, Farnaz ; Ghahremani, Mohammad Hossein ; Ostad, Seyed Nasser ; Atyabi, Fatemeh ; Seyedabadi, Mohammad ; Malekshahi, Mazda Rad ; Amini, Mohsen ; Dinarvand, Rassoul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-d804b3440fc785a40ca2e62c282731baec75e87487057fd59d63e75d3b2a15e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - pharmacokinetics</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Chromatography, High Pressure Liquid</topic><topic>docetaxel</topic><topic>Drug Carriers</topic><topic>Endocytosis - physiology</topic><topic>Excipients</topic><topic>Folate</topic><topic>Folate Receptors, GPI-Anchored</topic><topic>Folic Acid - chemistry</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Lactic Acid - chemistry</topic><topic>Medical sciences</topic><topic>nanoparticle</topic><topic>Nanoparticles</topic><topic>nanotechnology</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>PLGA</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyglycolic Acid - chemistry</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>targeted delivery</topic><topic>Taxoids - administration & dosage</topic><topic>Taxoids - pharmacokinetics</topic><topic>Taxoids - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Esmaeili, Farnaz</creatorcontrib><creatorcontrib>Ghahremani, Mohammad Hossein</creatorcontrib><creatorcontrib>Ostad, Seyed Nasser</creatorcontrib><creatorcontrib>Atyabi, Fatemeh</creatorcontrib><creatorcontrib>Seyedabadi, Mohammad</creatorcontrib><creatorcontrib>Malekshahi, Mazda Rad</creatorcontrib><creatorcontrib>Amini, Mohsen</creatorcontrib><creatorcontrib>Dinarvand, Rassoul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of drug targeting</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Esmaeili, Farnaz</au><au>Ghahremani, Mohammad Hossein</au><au>Ostad, Seyed Nasser</au><au>Atyabi, Fatemeh</au><au>Seyedabadi, Mohammad</au><au>Malekshahi, Mazda Rad</au><au>Amini, Mohsen</au><au>Dinarvand, Rassoul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Folate-receptor-targeted delivery of docetaxel nanoparticles prepared by PLGA-PEG-folate conjugate</atitle><jtitle>Journal of drug targeting</jtitle><addtitle>J Drug Target</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>16</volume><issue>5</issue><spage>415</spage><epage>423</epage><pages>415-423</pages><issn>1061-186X</issn><eissn>1029-2330</eissn><abstract>For folate-receptor-targeted anticancer therapy, docetaxel (DTX) nanoparticles (NPs) were produced employing polylactide-co-glycolide-polyethylene glycol-folate (PLGA-PEG-FOL) conjugate. The FOL-conjugated di-block copolymer was synthesized by coupling the PLGA-PEG-NH2 di-block copolymer with an activated folic acid. It was expected that FOL moieties were exposed on the micellar surface.
The conjugates assisted in the formation of DTX NPs with an average size of 200 nm in diameter through an emulsification/solvent diffusion method. The FOL-targeted NPs showed a greater extent of intracellular uptake in FOL-receptor-positive cancer cells (SKOV3) in comparison with the non-targeted NPs, indicating that the FOL-receptor-mediated endocytosis mechanism could have a role in the cellular uptake of NPs. These results suggested that FOL-targeted DTX NPs could be a potentially useful delivery system for FOL-receptor-positive cancer cells.</abstract><cop>Abington</cop><pub>Informa UK Ltd</pub><pmid>18569286</pmid><doi>10.1080/10611860802088630</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1061-186X |
| ispartof | Journal of drug targeting, 2008-01, Vol.16 (5), p.415-423 |
| issn | 1061-186X 1029-2330 |
| language | eng |
| recordid | cdi_crossref_primary_10_1080_10611860802088630 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Biological and medical sciences Carrier Proteins - metabolism Cell Line, Tumor Cell Survival - drug effects Chromatography, High Pressure Liquid docetaxel Drug Carriers Endocytosis - physiology Excipients Folate Folate Receptors, GPI-Anchored Folic Acid - chemistry General pharmacology Humans Lactic Acid - chemistry Medical sciences nanoparticle Nanoparticles nanotechnology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments PLGA Polyethylene Glycols - chemistry Polyglycolic Acid - chemistry Receptors, Cell Surface - metabolism targeted delivery Taxoids - administration & dosage Taxoids - pharmacokinetics Taxoids - pharmacology |
| title | Folate-receptor-targeted delivery of docetaxel nanoparticles prepared by PLGA-PEG-folate conjugate |
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