Mucoadhesive microspheres for nasal administration of cyclodextrins

The aim of this study was to examine the in vitro capacity of cyclodextrins to interfere on the β-amyloid fibril formation; then, mucoadhesive microspheres containing cyclodextrins were prepared and characterised as nasal delivery system for brain targeting. Eight batches of microspheres containing...

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Bibliographic Details
Published in:Journal of drug targeting 2009-02, Vol.17 (2), p.168-179
Main Authors: Gavini, Elisabetta, Rassu, Giovanna, Haukvik, Tone, Lanni, Cristina, Racchi, Marco, Giunchedi, Paolo
Format: Article
Language:English
Subjects:
2-Hydroxypropyl-beta-cyclodextrin
Adhesiveness
Adhesives - chemistry
Alginates - chemistry
Amyloid beta-Peptides - pharmacology
Animals
beta-Cyclodextrins - administration & dosage
beta-Cyclodextrins - chemistry
Biological and medical sciences
Brain - metabolism
brain targeting
Cell Line, Tumor
Chitosan - chemistry
Cyclodextrin
Drug Compounding
Drug Delivery Systems
General pharmacology
Humans
Lasers
Light
Medical sciences
Microscopy, Electron, Scanning
Microspheres
mucoadhesive microspheres
nasal drug delivery
Nasal Mucosa - chemistry
nose-to-brain transport
Particle Size
Permeability
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymers - chemistry
Scattering, Radiation
Sheep
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Summary:The aim of this study was to examine the in vitro capacity of cyclodextrins to interfere on the β-amyloid fibril formation; then, mucoadhesive microspheres containing cyclodextrins were prepared and characterised as nasal delivery system for brain targeting. Eight batches of microspheres containing chitosan or alginate loaded with β-cyclodextrin or hydroxypropyl-β-cyclodextrin in two different cyclodextrin to polymer ratios were produced by spray drying. The results show that none of the tested CDs has direct cellular toxicity and they protect the cell viability from β-peptide. The microspheres prepared are characterised by small particle sizes, ability to absorb water and to delay the in vitro dissolution rate of the CDs; good ex vivo mucoadhesive properties of the formulations are assessed. The microsphere properties are influenced by the kind of polymer, of cyclodextrin and by cyclodextrin to polymer ratio used. In particular, the alginate formulation containing the higher cyclodextrin content shows the best performance.
ISSN:1061-186X
1029-2330
DOI:10.1080/10611860802556842