Manganese dioxide (MnO2) based nanomaterials for cancer therapies and theranostics

Today, cancer still poses a serious threat to human, but there is no exact cure. Therefore, exploring to accomplish high therapeutic performance is a challenging and urgent task. Since the nanoparticles unique properties were discovered, they have displayed promising potential for more effective the...

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Bibliographic Details
Published in:Journal of drug targeting 2021-10, Vol.29 (9), p.911-924
Main Authors: Zhu, Dan, Zhu, Xiao-Hua, Ren, Shen-Zhen, Lu, Ya-Dong, Zhu, Hai-Liang
Format: Article
Language:English
Subjects:
Animals
cancer theranostics
cancer therapy
Drug Delivery Systems
Humans
Immunotherapy - methods
magnetic resonance imaging
Manganese Compounds - administration & dosage
Manganese Compounds - pharmacology
Manganese dioxide
Nanostructures
Neoplasms - drug therapy
Oxides - administration & dosage
Oxides - pharmacology
Photochemotherapy - methods
photodynamic therapy
Theranostic Nanomedicine
TME regulation
Tumor Microenvironment - drug effects
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Summary:Today, cancer still poses a serious threat to human, but there is no exact cure. Therefore, exploring to accomplish high therapeutic performance is a challenging and urgent task. Since the nanoparticles unique properties were discovered, they have displayed promising potential for more effective therapies and have been widely used in photodynamic therapy (PDT) and radiation therapy (RT). However, some special properties of the tumour microenvironment (TME) have seriously affected the therapeutic outcomes, so the modulation of the TME becomes critical. Manganese dioxide (MnO 2 ), as a transition metal oxide, has been widely used in biomedical fields with special physical and chemical properties, especially in regulating the TME. Furthermore, MnO 2 has widely applications in various cancer treatments, such as PDT, chemodynamic therapy (CDT), immunotherapy, and some specific collaborative treatment. Herein, we reviewed the recent applications of MnO 2 modified nanomaterials in tumour therapies and theranostics, including TME regulation, controlled drug loading/delivery/release, and imaging.
ISSN:1061-186X
1029-2330
DOI:10.1080/1061186X.2020.1815209