In vitro evaluation of alpha-tocopherol loaded carboxymethylcellulose chitosan copolymers as wound dressing materials

The hydrogel is a biopolymer exhibiting swelling behaviour involving a significant amount of water due to its insoluble, three-dimensional network structure when exposed to the aqueous medium, and allows its use in wound dressings. In the present study, a hydrogel was synthesized from chitosan and c...

Full description

Saved in:
Bibliographic Details
Published in:Materials technology (New York, N.Y.) N.Y.), 2019-06, Vol.34 (7), p.386-393
Main Authors: Bayindir Bilgic, Melike, Lacin, Nelisa Turkoglu, Berber, Hale, Mansuroglu, Banu
Format: Article
Language:English
Subjects:
Hydrogel
wound dressing
wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The hydrogel is a biopolymer exhibiting swelling behaviour involving a significant amount of water due to its insoluble, three-dimensional network structure when exposed to the aqueous medium, and allows its use in wound dressings. In the present study, a hydrogel was synthesized from chitosan and carboxymethylcellulose (CMC) polymers as a result of a chemical reaction at which N,N'-methylenebisacrylamide (MBA) was used as a cross-linker and ammonium persulfate (APS) as initiator-catalyst. Characteristic features of the synthesized hydrogel were determined by FTIR (Fourier Transform Infrared Spectroscopy), BET (Brunauer, Emmet and Teller) analyses. Alpha-Tocopherol release profile from the membrane was determined via ESI-MS using LC/Q-TOF. Cell adhesion and proliferation was observed by 3-[4,5-dimethyl-2-thiazolyl]-diphenyl tetrazolium bromide (MTT) method. The results revealed that hydrogels loaded alpha-Tocopherol is efficient for stimulating the healing process.
ISSN:1066-7857
1753-5557
DOI:10.1080/10667857.2019.1573944