Tyrosine nitration: Localisation, quantification, consequences for protein function and signal transduction

The nitration of free tyrosine or protein tyrosine residues generates 3-nitrotyrosine the detection of which has been utilised as a footprint for the in vivo formation of peroxynitrite and other reactive nitrogen species. The detection of 3-nitrotyrosine by analytical and immunological techniques ha...

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Bibliographic Details
Published in:Free radical research 2001-01, Vol.34 (6), p.541-581
Main Authors: Greenacre, Stan A.B., Ischiropoulos, Harry
Format: Article
Language:English
Subjects:
3-nitrotyrosine
Animals
Disease
Humans
Nitrates - metabolism
peroxynitrite
protein nitration
Proteins - metabolism
Proteins - physiology
reactive nitrogen species
Signal Transduction
Tyrosine - analogs & derivatives
Tyrosine - analysis
Tyrosine - metabolism
Tyrosine - physiology
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Summary:The nitration of free tyrosine or protein tyrosine residues generates 3-nitrotyrosine the detection of which has been utilised as a footprint for the in vivo formation of peroxynitrite and other reactive nitrogen species. The detection of 3-nitrotyrosine by analytical and immunological techniques has established that tyrosine nitration occurs under physiological conditions and levels increase in most disease states. This review provides an updated, comprehensive and detailed summary of the tissue, cellular and specific protein localisation of 3-nitrotyrosine and its quantification. The potential consequences of nitration to protein function and the pathogenesis of disease are also examined together with the possible effects of protein nitration on signal transduction pathways and on the metabolism of proteins.
ISSN:1071-5762
1029-2470
DOI:10.1080/10715760100300471