Tyrosine nitration: Localisation, quantification, consequences for protein function and signal transduction

The nitration of free tyrosine or protein tyrosine residues generates 3-nitrotyrosine the detection of which has been utilised as a footprint for the in vivo formation of peroxynitrite and other reactive nitrogen species. The detection of 3-nitrotyrosine by analytical and immunological techniques ha...

Full description

Saved in:
Bibliographic Details
Published in:Free radical research 2001-01, Vol.34 (6), p.541-581
Main Authors: Greenacre, Stan A.B., Ischiropoulos, Harry
Format: Article
Language:English
Subjects:
3-nitrotyrosine
Animals
Disease
Humans
Nitrates - metabolism
peroxynitrite
protein nitration
Proteins - metabolism
Proteins - physiology
reactive nitrogen species
Signal Transduction
Tyrosine - analogs & derivatives
Tyrosine - analysis
Tyrosine - metabolism
Tyrosine - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c371t-c1fcb4581a2df8701aa1812f13aecf1b687adb87de0586659d201beee4e613bf3
cites cdi_FETCH-LOGICAL-c371t-c1fcb4581a2df8701aa1812f13aecf1b687adb87de0586659d201beee4e613bf3
container_end_page 581
container_issue 6
container_start_page 541
container_title Free radical research
container_volume 34
creator Greenacre, Stan A.B.
Ischiropoulos, Harry
description The nitration of free tyrosine or protein tyrosine residues generates 3-nitrotyrosine the detection of which has been utilised as a footprint for the in vivo formation of peroxynitrite and other reactive nitrogen species. The detection of 3-nitrotyrosine by analytical and immunological techniques has established that tyrosine nitration occurs under physiological conditions and levels increase in most disease states. This review provides an updated, comprehensive and detailed summary of the tissue, cellular and specific protein localisation of 3-nitrotyrosine and its quantification. The potential consequences of nitration to protein function and the pathogenesis of disease are also examined together with the possible effects of protein nitration on signal transduction pathways and on the metabolism of proteins.
doi_str_mv 10.1080/10715760100300471
format article
fullrecord <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_10715760100300471</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>11697033</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-c1fcb4581a2df8701aa1812f13aecf1b687adb87de0586659d201beee4e613bf3</originalsourceid><addsrcrecordid>eNp9UMtOwzAQtBAISuEDuCB_AIHdOIlT4IIqXlIlLuUcOY5NDand2olQ_x73ISGE1NPurGZGO0PIBcI1Qgk3CBxzXgACMICM4wEZIKSjJM04HK53jkkkpCfkNIRPAGRZzo_JCWIx4sDYgHxNV94FYxW1pvOiM87e0omTojVhg67oshe2M9rIHZbOBrXslZUqUO08XXjXKWOp7q1cU6iwDQ3mw4qWRk8bmn5zPyNHWrRBne_mkLw_PU7HL8nk7fl1_DBJJOPYJRK1rLO8RJE2uuSAQmCJqUYmlNRYFyUXTV3yRkFeFkU-alLAWimVqQJZrdmQ4NZXxmjBK10tvJkLv6oQqnVx1b_iouZyq1n09Vw1v4pdU5FwvyUYGzPPxbfzbVN1YtU6r2NIaULF9vnf_ZHPlGi7mRReVZ-u97GqsOe7HzpjkNQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Tyrosine nitration: Localisation, quantification, consequences for protein function and signal transduction</title><source>Taylor and Francis Science and Technology Collection</source><creator>Greenacre, Stan A.B. ; Ischiropoulos, Harry</creator><creatorcontrib>Greenacre, Stan A.B. ; Ischiropoulos, Harry</creatorcontrib><description>The nitration of free tyrosine or protein tyrosine residues generates 3-nitrotyrosine the detection of which has been utilised as a footprint for the in vivo formation of peroxynitrite and other reactive nitrogen species. The detection of 3-nitrotyrosine by analytical and immunological techniques has established that tyrosine nitration occurs under physiological conditions and levels increase in most disease states. This review provides an updated, comprehensive and detailed summary of the tissue, cellular and specific protein localisation of 3-nitrotyrosine and its quantification. The potential consequences of nitration to protein function and the pathogenesis of disease are also examined together with the possible effects of protein nitration on signal transduction pathways and on the metabolism of proteins.</description><identifier>ISSN: 1071-5762</identifier><identifier>EISSN: 1029-2470</identifier><identifier>DOI: 10.1080/10715760100300471</identifier><identifier>PMID: 11697033</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>3-nitrotyrosine ; Animals ; Disease ; Humans ; Nitrates - metabolism ; peroxynitrite ; protein nitration ; Proteins - metabolism ; Proteins - physiology ; reactive nitrogen species ; Signal Transduction ; Tyrosine - analogs &amp; derivatives ; Tyrosine - analysis ; Tyrosine - metabolism ; Tyrosine - physiology</subject><ispartof>Free radical research, 2001-01, Vol.34 (6), p.541-581</ispartof><rights>2001 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-c1fcb4581a2df8701aa1812f13aecf1b687adb87de0586659d201beee4e613bf3</citedby><cites>FETCH-LOGICAL-c371t-c1fcb4581a2df8701aa1812f13aecf1b687adb87de0586659d201beee4e613bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11697033$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greenacre, Stan A.B.</creatorcontrib><creatorcontrib>Ischiropoulos, Harry</creatorcontrib><title>Tyrosine nitration: Localisation, quantification, consequences for protein function and signal transduction</title><title>Free radical research</title><addtitle>Free Radic Res</addtitle><description>The nitration of free tyrosine or protein tyrosine residues generates 3-nitrotyrosine the detection of which has been utilised as a footprint for the in vivo formation of peroxynitrite and other reactive nitrogen species. The detection of 3-nitrotyrosine by analytical and immunological techniques has established that tyrosine nitration occurs under physiological conditions and levels increase in most disease states. This review provides an updated, comprehensive and detailed summary of the tissue, cellular and specific protein localisation of 3-nitrotyrosine and its quantification. The potential consequences of nitration to protein function and the pathogenesis of disease are also examined together with the possible effects of protein nitration on signal transduction pathways and on the metabolism of proteins.</description><subject>3-nitrotyrosine</subject><subject>Animals</subject><subject>Disease</subject><subject>Humans</subject><subject>Nitrates - metabolism</subject><subject>peroxynitrite</subject><subject>protein nitration</subject><subject>Proteins - metabolism</subject><subject>Proteins - physiology</subject><subject>reactive nitrogen species</subject><subject>Signal Transduction</subject><subject>Tyrosine - analogs &amp; derivatives</subject><subject>Tyrosine - analysis</subject><subject>Tyrosine - metabolism</subject><subject>Tyrosine - physiology</subject><issn>1071-5762</issn><issn>1029-2470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp9UMtOwzAQtBAISuEDuCB_AIHdOIlT4IIqXlIlLuUcOY5NDand2olQ_x73ISGE1NPurGZGO0PIBcI1Qgk3CBxzXgACMICM4wEZIKSjJM04HK53jkkkpCfkNIRPAGRZzo_JCWIx4sDYgHxNV94FYxW1pvOiM87e0omTojVhg67oshe2M9rIHZbOBrXslZUqUO08XXjXKWOp7q1cU6iwDQ3mw4qWRk8bmn5zPyNHWrRBne_mkLw_PU7HL8nk7fl1_DBJJOPYJRK1rLO8RJE2uuSAQmCJqUYmlNRYFyUXTV3yRkFeFkU-alLAWimVqQJZrdmQ4NZXxmjBK10tvJkLv6oQqnVx1b_iouZyq1n09Vw1v4pdU5FwvyUYGzPPxbfzbVN1YtU6r2NIaULF9vnf_ZHPlGi7mRReVZ-u97GqsOe7HzpjkNQ</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Greenacre, Stan A.B.</creator><creator>Ischiropoulos, Harry</creator><general>Informa UK Ltd</general><general>Taylor &amp; Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20010101</creationdate><title>Tyrosine nitration: Localisation, quantification, consequences for protein function and signal transduction</title><author>Greenacre, Stan A.B. ; Ischiropoulos, Harry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-c1fcb4581a2df8701aa1812f13aecf1b687adb87de0586659d201beee4e613bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>3-nitrotyrosine</topic><topic>Animals</topic><topic>Disease</topic><topic>Humans</topic><topic>Nitrates - metabolism</topic><topic>peroxynitrite</topic><topic>protein nitration</topic><topic>Proteins - metabolism</topic><topic>Proteins - physiology</topic><topic>reactive nitrogen species</topic><topic>Signal Transduction</topic><topic>Tyrosine - analogs &amp; derivatives</topic><topic>Tyrosine - analysis</topic><topic>Tyrosine - metabolism</topic><topic>Tyrosine - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greenacre, Stan A.B.</creatorcontrib><creatorcontrib>Ischiropoulos, Harry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Free radical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greenacre, Stan A.B.</au><au>Ischiropoulos, Harry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tyrosine nitration: Localisation, quantification, consequences for protein function and signal transduction</atitle><jtitle>Free radical research</jtitle><addtitle>Free Radic Res</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>34</volume><issue>6</issue><spage>541</spage><epage>581</epage><pages>541-581</pages><issn>1071-5762</issn><eissn>1029-2470</eissn><abstract>The nitration of free tyrosine or protein tyrosine residues generates 3-nitrotyrosine the detection of which has been utilised as a footprint for the in vivo formation of peroxynitrite and other reactive nitrogen species. The detection of 3-nitrotyrosine by analytical and immunological techniques has established that tyrosine nitration occurs under physiological conditions and levels increase in most disease states. This review provides an updated, comprehensive and detailed summary of the tissue, cellular and specific protein localisation of 3-nitrotyrosine and its quantification. The potential consequences of nitration to protein function and the pathogenesis of disease are also examined together with the possible effects of protein nitration on signal transduction pathways and on the metabolism of proteins.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>11697033</pmid><doi>10.1080/10715760100300471</doi><tpages>41</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1071-5762
ispartof Free radical research, 2001-01, Vol.34 (6), p.541-581
issn 1071-5762
1029-2470
language eng
recordid cdi_crossref_primary_10_1080_10715760100300471
source Taylor and Francis Science and Technology Collection
subjects 3-nitrotyrosine
Animals
Disease
Humans
Nitrates - metabolism
peroxynitrite
protein nitration
Proteins - metabolism
Proteins - physiology
reactive nitrogen species
Signal Transduction
Tyrosine - analogs & derivatives
Tyrosine - analysis
Tyrosine - metabolism
Tyrosine - physiology
title Tyrosine nitration: Localisation, quantification, consequences for protein function and signal transduction
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T07%3A15%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tyrosine%20nitration:%20Localisation,%20quantification,%20consequences%20for%20protein%20function%20and%20signal%20transduction&rft.jtitle=Free%20radical%20research&rft.au=Greenacre,%20Stan%20A.B.&rft.date=2001-01-01&rft.volume=34&rft.issue=6&rft.spage=541&rft.epage=581&rft.pages=541-581&rft.issn=1071-5762&rft.eissn=1029-2470&rft_id=info:doi/10.1080/10715760100300471&rft_dat=%3Cpubmed_cross%3E11697033%3C/pubmed_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c371t-c1fcb4581a2df8701aa1812f13aecf1b687adb87de0586659d201beee4e613bf3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/11697033&rfr_iscdi=true