Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise

Seventeen volunteer male professional cyclists were randomly assigned to control or supplemented (6 g L-citrulline-malate) groups and participated in a cycling stage. Blood samples were taken in basal conditions, after the race and 3 h post-race. Citrulline supplementation significantly increased pl...

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Bibliographic Details
Published in:Free radical research 2009-01, Vol.43 (9), p.828-835
Main Authors: Sureda, Antoni, Córdova, Alfredo, Ferrer, Miguel D., Tauler, Pedro, Pérez, Gerardo, Tur, Josep A., Pons, Antoni
Format: Article
Language:English
Subjects:
Administration, Oral
Arginine - blood
Bicycling
Citrulline - administration & dosage
Citrulline - analogs & derivatives
Citrulline - blood
Creatine Kinase - blood
Dietary Supplements
DNA Damage
Double-Blind Method
Exercise
Humans
L-citrulline
L-Lactate Dehydrogenase - blood
Malates - administration & dosage
Malates - blood
Male
malondialdehyde
Malondialdehyde - blood
Neutrophil Activation - drug effects
Neutrophils - drug effects
Neutrophils - metabolism
nitric oxide
Nitric Oxide - blood
Nitrites - blood
polymorphonuclear neutrophils
Respiratory Burst - drug effects
Time Factors
Young Adult
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Summary:Seventeen volunteer male professional cyclists were randomly assigned to control or supplemented (6 g L-citrulline-malate) groups and participated in a cycling stage. Blood samples were taken in basal conditions, after the race and 3 h post-race. Citrulline supplementation significantly increased plasma concentration of both arginine and citrulline after the stage only in the supplemented group. Polymorphonuclear neutrophils (PMNs) from controls responded to exercise with a progressive decrease in ROS production. Supplemented PMNs significantly increased ROS production after exercise compared to basal values and diminished to values lower than basal at recovery. PMN nitrite concentration was significantly higher after exercise and recovery only in the supplemented group. Markers of oxidative damage-CK, LDH, malondialdehyde-and DNA damage remained unchanged in both groups. In conclusion, oral L-citrulline administration previous to a cycling stage increases plasma arginine availability for NO synthesis and PMNs priming for oxidative burst without oxidative damage.
ISSN:1071-5762
1029-2470
DOI:10.1080/10715760903071664