Oxidation of LDL and extent of peripheral atherosclerosis

Evidence has accumulated for oxidative modification of low-density lipoproteins (LDL) to play an important role in the atherogenic process. Therefore, we investigated the relation between susceptibility of LDL to oxidation and risk of peripheral atherosclerosis among 249 men between 45 and 80 years...

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Bibliographic Details
Published in:Free radical research 1999-01, Vol.31 (2), p.129-139
Main Authors: van de Vijver, Lucy P.L., Kardinaal, Alwine F.M., van Duyvenvoorde, Wim, Kruijssen, Dick A.C.M., Grobbee, Diederick E., van Poppel, Geert, Princen, Hans M.G.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
ankle-arm index
Anticoagulants - therapeutic use
Antihypertensive Agents - therapeutic use
Arteriosclerosis - blood
Arteriosclerosis - therapy
Aspirin - therapeutic use
Cholesterol, Dietary - administration & dosage
Coumarins - therapeutic use
Diet, Fat-Restricted
Humans
LDL composition
LDL oxidation
Lipid Peroxidation
Lipoproteins, LDL - metabolism
Male
Middle Aged
Odds Ratio
peripheral atherosclerosis
resistance time
Risk Factors
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Summary:Evidence has accumulated for oxidative modification of low-density lipoproteins (LDL) to play an important role in the atherogenic process. Therefore, we investigated the relation between susceptibility of LDL to oxidation and risk of peripheral atherosclerosis among 249 men between 45 and 80 years of age. The ankle-arm index was calculated for both legs as the ratio of systolic blood pressure in the leg divided by the arm systolic blood pressure. The lowest of both ankle-arm indices was used to categorize subjects. Thirty-nine men with an ankle-arm index
ISSN:1071-5762
1029-2470
DOI:10.1080/10715769900301641