pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms

Oral administration is a desirable alternative of parenteral administration due to the convenience and increased compliance to patients, especially for chronic diseases that require frequent administration. The oral drug delivery is a dynamic research field despite the numerous challenges limiting t...

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Bibliographic Details
Published in:Drug delivery 2017-01, Vol.24 (1), p.569-581
Main Authors: Liu, Lin, Yao, WenDong, Rao, YueFeng, Lu, XiaoYang, Gao, JianQing
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Bacterial infections
bioavailability
Biological Availability
controlled release
Drug Carriers - administration & dosage
Drug Carriers - adverse effects
Drug Carriers - chemistry
Drug Compounding - trends
drug delivery
Drug delivery systems
Drug Stability
Humans
Hydrogels - administration & dosage
Hydrogels - adverse effects
Hydrogels - chemistry
Hydrogen-Ion Concentration
Inflammatory bowel disease
Intestinal Absorption - drug effects
Microspheres
Nanoparticles - administration & dosage
Nanoparticles - adverse effects
Nanoparticles - chemistry
oral delivery
pH-Responsive
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Pharmacokinetics
Review
Tablets - administration & dosage
Tablets - adverse effects
Tablets - chemistry
Transdermal medication
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Summary:Oral administration is a desirable alternative of parenteral administration due to the convenience and increased compliance to patients, especially for chronic diseases that require frequent administration. The oral drug delivery is a dynamic research field despite the numerous challenges limiting their effective delivery, such as enzyme degradation, hydrolysis and low permeability of intestinal epithelium in the gastrointestinal (GI) tract. pH-Responsive carriers offer excellent potential as oral therapeutic systems due to enhancing the stability of drug delivery in stomach and achieving controlled release in intestines. This review provides a wide perspective on current status of pH-responsive oral drug delivery systems prepared mainly with organic polymers or inorganic materials, including the strategies used to overcome GI barriers, the challenges in their development and future prospects, with focus on technology trends to improve the bioavailability of orally delivered drugs, the mechanisms of drug release from pH-responsive oral formulations, and their application for drug delivery, such as protein and peptide therapeutics, vaccination, inflammatory bowel disease (IBD) and bacterial infections.
ISSN:1071-7544
1521-0464
DOI:10.1080/10717544.2017.1279238