Interactions of Some Organic Solvents: Hydrocarbons and Chloroalkene

Metabolic and toxicodynamic interactions of some organic solvents in rats repeatedly treated with medium dose levels were examined. It was shown that both n-hexane and ethylbenzene significantly inhibited tetrachloroethy-lene metabolism during a 2-week period. n-Hexane and tetrachloroethylene enhanc...

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Published in:International journal of occupational safety and ergonomics 2001-01, Vol.7 (1), p.35-47
Main Authors: Skowroń, Jolanta, Miranowicz-Dzierżawska, Katarzyna, Zapór, Lidia, Gołofit-Szymczak, Małgorzata, Starek, Andrzej
Format: Article
Language:English
Subjects:
Animals
Benzene Derivatives - metabolism
Benzene Derivatives - toxicity
chloroalkene
ethylbenzene
Hexanes - metabolism
Hexanes - toxicity
Male
metabolic interactions
n-Hexane
Poland
Rats
Rats, Wistar
Solvents - toxicity
tetrachloroethylene
Tetrachloroethylene - metabolism
Tetrachloroethylene - toxicity
toxicodynamic interactions
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Summary:Metabolic and toxicodynamic interactions of some organic solvents in rats repeatedly treated with medium dose levels were examined. It was shown that both n-hexane and ethylbenzene significantly inhibited tetrachloroethy-lene metabolism during a 2-week period. n-Hexane and tetrachloroethylene enhanced metabolism of ethylbenzene whereas ethylbenzene suppressed n-hexane metabolism only at the end of the experiment. Biochemical changes, especially the drop in the level of non-protein sulfhydryl groups in tissues of rats treated with organic solvent mixtures, were significantly less pronounced than those observed after these chemicals were administered separately. These results demonstrate that metabolic interactions between hydrocarbons and chloroalkene may lead to a modification of the biological response to these compounds.
ISSN:1080-3548
2376-9130
DOI:10.1080/10803548.2001.11076475