A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study

Herbal utilization, as an antidiabetes agent, is an interesting topic to find acceptable herbal drugs to decrease blood glucose levels. The aim of this review is to evaluate the potency of selected herbal medicines to reduce blood glucose levels and to identify the chemical compounds responsible for...

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Bibliographic Details
Published in:International journal of food properties 2023-09, Vol.26 (1), p.1414-1425
Main Authors: Ahda, Mustofa, Jaswir, Irwandi, Khatib, Alfi, Ahmed, Qamar Uddin, Mahfudh, Nurkhasanah, Ardini, Yunita Dewi
Format: Article
Language:English
Subjects:
Andrographis paniculata
Anti-diabetes
Antidiabetics
Blood glucose
clinical study
Diabetes
Diabetes mellitus
Herbal medicine
herbal medicines
mechanisms of action
Secretion
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Summary:Herbal utilization, as an antidiabetes agent, is an interesting topic to find acceptable herbal drugs to decrease blood glucose levels. The aim of this review is to evaluate the potency of selected herbal medicines to reduce blood glucose levels and to identify the chemical compounds responsible for reducing glucose. The mechanisms of action of different herbal medicines used might be also different. The reduction of blood glucose levels by Aloe vera, Andrographis paniculata, and Trigonella foenum-graecum through minimum 3 mechanisms of action, such as increased GLP-1 secretion and inhibited amylase, glucosidase, and SGLT 2. While Andrographis paniculata has more than 4 mechanisms of action, such as increasing GLP secretion, activating PPAR ɣ-receptor, and also inhibiting amylase, glucosidase, and SGLT 2 but it did not inhibit DPP 4 in diabetic patients.
ISSN:1094-2912
1532-2386
DOI:10.1080/10942912.2023.2215475