Overexpression of SRG3/SWI3 protein disrupts the cell cycle progression in mature t cells and yeast

Mouse T cells overexpressing the SRG3 protein displayed morphological changes; the cells were enlarged and their shapes were irregular compared to the normal parental cells. In addition, growth rate of the cells was dramatically reduced and their DNA contents were increased. The increased DNA conten...

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Bibliographic Details
Published in:Korean journal of biological sciences 2002-01, Vol.6 (4), p.335-339
Main Authors: Jeon, Sung Ho, Choi, Young Il, Seong, Rho Hyun
Format: Article
Language:English
Subjects:
Cell cycle
Polyploidy
SRG3
SWI3
T cell
Yeast
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Summary:Mouse T cells overexpressing the SRG3 protein displayed morphological changes; the cells were enlarged and their shapes were irregular compared to the normal parental cells. In addition, growth rate of the cells was dramatically reduced and their DNA contents were increased. The increased DNA contents were due to an increase in number of chromosomes in these cells. We have observed similar results in S. cerevisiae cells overexpressing the yeast SWC protein. Yeast cells overexpressing SWC protein displayed the phenotypes of highly elongated buds and 2C DNA content. These results suggest that the SRG3/SWC protein plays an important role in cell growth and cell cycle progression.
ISSN:1226-5071
DOI:10.1080/12265071.2002.9647673