3-methoxy aroylhydrazones - free radicals scavenging, anticancer and cytoprotective potency

Objective: This study aimed to determine the capability of newly designed 3-methoxy derivatives of salicylaldehyde benzoylhydrazone to influence the oxidative stress processes and to test their in vitro cytotoxicity. Methods: We have used chemiluminescent and spectrophotometric model systems contain...

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Bibliographic Details
Published in:Redox report : communications in free radical research 2017-11, Vol.22 (6), p.408-417
Main Authors: Hristova-Avakumova, Nadya, Yoncheva, Krassimira, Nikolova-Mladenova, Boryana, Traykov, Trayko, Momekov, Georgi, Hadjimitova, Vera
Format: Article
Language:English
Subjects:
antioxidant activity
Antioxidants - pharmacology
Cell Line
Cell Survival - drug effects
chemiluminescence
excytotoxicity
Free Radical Scavengers - pharmacology
HEK293 Cells
Hep G2 Cells
Humans
Hydrazones
Hydrazones - pharmacology
Hydroxyl Radical - metabolism
Oxidation-Reduction - drug effects
Oxidative Stress - drug effects
polysaccharide particles
Reactive Oxygen Species - metabolism
Superoxides - metabolism
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Summary:Objective: This study aimed to determine the capability of newly designed 3-methoxy derivatives of salicylaldehyde benzoylhydrazone to influence the oxidative stress processes and to test their in vitro cytotoxicity. Methods: We have used chemiluminescent and spectrophotometric model systems containing different types of reactive oxygen species (OH ● , OCl ─ and O 2 ─● ). The hydrazones effect on the viability of Hep-G2, HEK-293 and SH-SY5Y cell lines was determined via MTT assay. Results: The comparative analysis of the C 50 values of the chemiluminescent investigation demonstrated moderate activity against the hydroxyl radicals (C 50  > 50 μmol/L) and remarkable reactivity in the systems containing a superoxide radical and a hypochlorous anion (C 50  
ISSN:1351-0002
1743-2928
DOI:10.1080/13510002.2016.1276256