Protection of cholinergic and antioxidant system contributes to the effect of Vitamin D 3 ameliorating memory dysfunction in sporadic dementia of Alzheimer's type

• Published in: Redox report : communications in free radical research 2019-01, Vol.24 (1), p.34-40
• Main Authors: Rodrigues, Marilia Valvassori, Gutierres, Jessié Martins, Carvalho, Fabiano, Lopes, Thauan Faccin, Antunes, Vitor, da Costa, Pauline, Pereira, Maria Estér, Schetinger, Maria Rosa Chitolina, Morsch, Vera M, de Andrade, Cinthia Melazzo
• Format: Article
• Language: English
• Subjects: Acetylcholinesterase - metabolism; Alzheimer Disease - metabolism; Animals; Antioxidants - metabolism; Ascorbic Acid - metabolism; Cholecalciferol - therapeutic use; Dementia - metabolism; Disease Models, Animal; Lipid Peroxidation - drug effects; Male; Memory - drug effects; Oxidative Stress - drug effects; Rats; Rats, Wistar; Reactive Oxygen Species - metabolism
• ISSN: 1351-0002; 1743-2928
• DOI: 10.1080/13510002.2019.1617514

Investigate Vitamin D (VD ) effect on the Acetylcholinesterase (AChE), oxidative damage and behavioral tests in animals subjected to Intracerebroventicular injection of Streptozotocin (ICV-STZ) simulating a Sporadic Dementia of Alzheimer's Type (SDAT) and treated with VD (21 days). Animals were divided into eight groups: Vehicle, VD12.5 μg/kg, VD42 μg/kg, VD125 μg/kg, STZ, STZ+VD12.5 μg/kg, STZ+VD42 μg/kg, STZ+VD125 μg/kg. VD prevented the increase in AChE in groups of VD42 µg/kg and VD125 µg/kg; in AChE of synaptossomes and TBARS levels prevented the increase in group VD125 µg/kg; in ROS levels there was not a significant difference; for the Carbonyl Content all doses prevented the increase. Total Thiols prevent the decrease in VD42 µg/kg and VD125 µg/kg, and Reduced Glutathione prevented the decrease in VD125 µg/kg, Oxidized Glutathione prevented the increase in VD125 µg/kg. In relation to behavioral tests, the VD prevented the increase in time to find (days 2 and 3), in the time to find the platform (day 3) and in time spent in the quadrant (day 2). However, in relation to crossings there was not difference in groups. These results indicated the therapeutic effect of the VD in model of STZ in rats.