The prognostic value of MR-proadrenomedullin in patients with acute coronary syndrome complicated by cardiogenic shock

Context: Cardiogenic shock (CS) still remains one of the main causes of death in acute myocardial infarction (AMI). Objective: The aim of this study was to evaluate the prognostic value of midregional (MR)-proadrenomedullin in AMI complicated by CS. Methods: Forty-seven consecutive patients were inc...

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Bibliographic Details
Published in:Biomarkers 2017-05, Vol.22 (3-4), p.296-303
Main Authors: Supeł, Karolina, Kacprzak, Michał, Zielińska, Marzenna
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - complications
Adrenomedullin - blood
Adult
Aged
Aged, 80 and over
Cardiogenic shock
Hospital Mortality
Humans
Middle Aged
MR-proadrenomedullin
myocardial infarction
Myocardial Infarction - complications
Prognosis
Prospective Studies
Protein Precursors - blood
Shock, Cardiogenic - complications
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Summary:Context: Cardiogenic shock (CS) still remains one of the main causes of death in acute myocardial infarction (AMI). Objective: The aim of this study was to evaluate the prognostic value of midregional (MR)-proadrenomedullin in AMI complicated by CS. Methods: Forty-seven consecutive patients were included in our prospective observational study. All patients underwent coronarography and successful percutaneous coronary intervention (PCI). Plasma levels of MR-proADM were measured by a immunofluorescence method. The primary endpoint of the study, defined as cardiovascular death, occurred in 17 patients (36%). Results and conclusion: Elevated plasma level of MR-proADM, determined 24 h after diagnosis of CS could be a predictor of in-hospital mortality in patients with AMI complicated by CS.
ISSN:1354-750X
1366-5804
DOI:10.1080/1354750X.2016.1252962