Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients

• Published in: Biomarkers 2017-11, Vol.22 (8), p.790-797
• Main Authors: Bonifačić, David, Aralica, Merica, Sotošek Tokmadžić, Vlatka, Rački, Valentino, Tuškan-Mohar, Lidija, Kučić, Natalia
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Autonomic nervous system; Biomarkers - urine; Brain Ischemia - complications; Brain Ischemia - diagnosis; Brain Ischemia - urine; Chromatography, Liquid; Female; homovanillic acid; Humans; immunodepression syndrome; ischaemic stroke; Male; Prognosis; prognostic biomarkers; Reference Values; Stroke - diagnosis; Stroke - etiology; Stroke - urine; vanillylmandelic acid; Vanilmandelic Acid - urine
• ISSN: 1354-750X; 1366-5804
• DOI: 10.1080/1354750X.2017.1351001

Background: Suitable biomarkers that have prognostic values are one of the key points of interest in ischaemic stroke. Increased sympathetic nervous system activity in ischaemic stroke causes multiple local and systemic effects that can be detrimental to the outcome. The mechanism of action is increased secretion and activity of catecholamines, whose end metabolic products are vanillylmandelic acid and homovanilic acid. Aim of our study was to determine whether these compounds can be used as potential prognostic biomarkers in ischaemic stroke, as a unique insight into the activity of the sympathetic nervous system. Methods: Urine samples of 96 patients with ischaemic stroke and transitory ischaemic attacks were analysed. Values of vanillylmandelic and homovanillic acids in urine were tested using liquid chromatography on the first and third day post-stroke. Severity of stroke was determined using the NIHSS scale, while functional outcome was determined using the Modified Rankin Scale. Results: Values of vanillylmandelic and homovanillic acids positively correlated with functional outcome of ischaemic stroke. Favorable outcomes correlated with decreased values, on contrary to increased values, which were associated with unfavourable outcomes. Conclusion: Determining the values of these compounds in the urine is an easily available prognostic tool for the ischaemic stroke outcome, while also influencing potential therapeutic changes.