Shorter (GT)n repeats in the haem-oxygenase 1 gene promoter are associated with better mid-term survival in subjects with coronary artery disease and abnormal ejection fraction

Haem oxygenase (HO)-1 is a rate-limiting enzyme for degrading haem into carbon monoxide. Subjects with longer GT repeats in the HO-1 gene (HMOX1) promoter are more likely to have coronary artery disease (CAD) and cardiovascular events. We retrospectively enrolled CAD subjects with an abnormal ejecti...

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Bibliographic Details
Published in:Biomarkers 2021-11, Vol.26 (8), p.732-736
Main Authors: Liang, Kae-Woei, Lee, Wen-Jane, Lee, Wen-Lieng, Wu, Jen-Pey, Sheu, Wayne H-H
Format: Article
Language:English
Subjects:
Aged
Coronary artery disease (CAD)
Coronary Artery Disease - genetics
Coronary Artery Disease - mortality
Coronary Artery Disease - physiopathology
Dinucleotide Repeats - genetics
Female
Gene Expression Regulation
Gene Frequency
Genotype
haem oxygenase (HO)-1
Heme Oxygenase-1 - genetics
HMOX1
Humans
left ventricular ejection fraction
Male
Middle Aged
promoter polymorphism
Promoter Regions, Genetic - genetics
Retrospective Studies
Stroke Volume - genetics
Stroke Volume - physiology
Survival Analysis
Survival Rate
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Summary:Haem oxygenase (HO)-1 is a rate-limiting enzyme for degrading haem into carbon monoxide. Subjects with longer GT repeats in the HO-1 gene (HMOX1) promoter are more likely to have coronary artery disease (CAD) and cardiovascular events. We retrospectively enrolled CAD subjects with an abnormal ejection fraction (EF)
ISSN:1354-750X
1366-5804
DOI:10.1080/1354750X.2021.1992650