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Shorter (GT)n repeats in the haem-oxygenase 1 gene promoter are associated with better mid-term survival in subjects with coronary artery disease and abnormal ejection fraction
Haem oxygenase (HO)-1 is a rate-limiting enzyme for degrading haem into carbon monoxide. Subjects with longer GT repeats in the HO-1 gene (HMOX1) promoter are more likely to have coronary artery disease (CAD) and cardiovascular events. We retrospectively enrolled CAD subjects with an abnormal ejecti...
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| Published in: | Biomarkers 2021-11, Vol.26 (8), p.732-736 |
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| Main Authors: | , , , , |
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| cites | cdi_FETCH-LOGICAL-c366t-556358509d2e6eebbf8e9c179a502d21f4344f600c64bb847fdbbbb8d63bf8e43 |
| container_end_page | 736 |
| container_issue | 8 |
| container_start_page | 732 |
| container_title | Biomarkers |
| container_volume | 26 |
| creator | Liang, Kae-Woei Lee, Wen-Jane Lee, Wen-Lieng Wu, Jen-Pey Sheu, Wayne H-H |
| description | Haem oxygenase (HO)-1 is a rate-limiting enzyme for degrading haem into carbon monoxide. Subjects with longer GT repeats in the HO-1 gene (HMOX1) promoter are more likely to have coronary artery disease (CAD) and cardiovascular events.
We retrospectively enrolled CAD subjects with an abnormal ejection fraction (EF) |
| doi_str_mv | 10.1080/1354750X.2021.1992650 |
| format | article |
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We retrospectively enrolled CAD subjects with an abnormal ejection fraction (EF) <50% from our catheterisation data (N = 670). Polymerase chain reactions were performed for amplifying the HMOX1 promoter GT repeating segment to determine the number of repeats.
In a median follow-up period of 40 months, 213 patients died. The distribution of genotype for HMOX1 promoter GT repeating segments SS, SL, and LL were significantly different (p < 0.001) between the dead (44.6%, 36.2%, 19.2%, respectively) and the survived (53.8%, 37.4%, 8.8%, respectively) (S allele: ≤30 repeats, L allele: >30 repeats). In Cox regression analysis, carrier of S allele (hazard ratio 0.665, p = 0.027), a higher EF (hazard ratio 0.037, p = 0.001), and revascularization with PCI were all negatively associated with all-cause death in subjects with CAD and abnormal EF.
Carrier of shorter (GT)
n
repeats of HMOX1 gene promoter was negatively correlated with death events in CAD patients with abnormal EF.</description><identifier>ISSN: 1354-750X</identifier><identifier>EISSN: 1366-5804</identifier><identifier>DOI: 10.1080/1354750X.2021.1992650</identifier><identifier>PMID: 34634993</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Aged ; Coronary artery disease (CAD) ; Coronary Artery Disease - genetics ; Coronary Artery Disease - mortality ; Coronary Artery Disease - physiopathology ; Dinucleotide Repeats - genetics ; Female ; Gene Expression Regulation ; Gene Frequency ; Genotype ; haem oxygenase (HO)-1 ; Heme Oxygenase-1 - genetics ; HMOX1 ; Humans ; left ventricular ejection fraction ; Male ; Middle Aged ; promoter polymorphism ; Promoter Regions, Genetic - genetics ; Retrospective Studies ; Stroke Volume - genetics ; Stroke Volume - physiology ; Survival Analysis ; Survival Rate</subject><ispartof>Biomarkers, 2021-11, Vol.26 (8), p.732-736</ispartof><rights>2021 Informa UK Limited, trading as Taylor & Francis Group 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-556358509d2e6eebbf8e9c179a502d21f4344f600c64bb847fdbbbb8d63bf8e43</citedby><cites>FETCH-LOGICAL-c366t-556358509d2e6eebbf8e9c179a502d21f4344f600c64bb847fdbbbb8d63bf8e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34634993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Kae-Woei</creatorcontrib><creatorcontrib>Lee, Wen-Jane</creatorcontrib><creatorcontrib>Lee, Wen-Lieng</creatorcontrib><creatorcontrib>Wu, Jen-Pey</creatorcontrib><creatorcontrib>Sheu, Wayne H-H</creatorcontrib><title>Shorter (GT)n repeats in the haem-oxygenase 1 gene promoter are associated with better mid-term survival in subjects with coronary artery disease and abnormal ejection fraction</title><title>Biomarkers</title><addtitle>Biomarkers</addtitle><description>Haem oxygenase (HO)-1 is a rate-limiting enzyme for degrading haem into carbon monoxide. Subjects with longer GT repeats in the HO-1 gene (HMOX1) promoter are more likely to have coronary artery disease (CAD) and cardiovascular events.
We retrospectively enrolled CAD subjects with an abnormal ejection fraction (EF) <50% from our catheterisation data (N = 670). Polymerase chain reactions were performed for amplifying the HMOX1 promoter GT repeating segment to determine the number of repeats.
In a median follow-up period of 40 months, 213 patients died. The distribution of genotype for HMOX1 promoter GT repeating segments SS, SL, and LL were significantly different (p < 0.001) between the dead (44.6%, 36.2%, 19.2%, respectively) and the survived (53.8%, 37.4%, 8.8%, respectively) (S allele: ≤30 repeats, L allele: >30 repeats). In Cox regression analysis, carrier of S allele (hazard ratio 0.665, p = 0.027), a higher EF (hazard ratio 0.037, p = 0.001), and revascularization with PCI were all negatively associated with all-cause death in subjects with CAD and abnormal EF.
Carrier of shorter (GT)
n
repeats of HMOX1 gene promoter was negatively correlated with death events in CAD patients with abnormal EF.</description><subject>Aged</subject><subject>Coronary artery disease (CAD)</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary Artery Disease - mortality</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Dinucleotide Repeats - genetics</subject><subject>Female</subject><subject>Gene Expression Regulation</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>haem oxygenase (HO)-1</subject><subject>Heme Oxygenase-1 - genetics</subject><subject>HMOX1</subject><subject>Humans</subject><subject>left ventricular ejection fraction</subject><subject>Male</subject><subject>Middle Aged</subject><subject>promoter polymorphism</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Retrospective Studies</subject><subject>Stroke Volume - genetics</subject><subject>Stroke Volume - physiology</subject><subject>Survival Analysis</subject><subject>Survival Rate</subject><issn>1354-750X</issn><issn>1366-5804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kctuFDEQRS1ERB7wCSAvw6Info97B4ogIEVikURiZ7nb1YyjbnuwuxPmr_jE2JkJS7ypknzuLVVdhN5TsqJEkwvKpVhL8nPFCKMr2rZMSfIKnVCuVCM1Ea9rL0VToWN0mvM9IZSzVr9Bx1woLtqWn6C_N5uYZkj4_Or2Y8AJtmDnjH3A8wbwxsLUxD-7XxBsBkxxaQBvU5xi1dgE2OYce29ncPjRzxvcwVy_Ju-aUiecl_TgH-xYLfPS3UNf7J_JPqYYbNoVm0LusPMZ6hQbHLZdiGkqKqgCHwMekn1u3qKjwY4Z3h3qGbr7-uX28ltz_ePq--Xn66YvB5gbKRWXWpLWMVAAXTdoaHu6bq0kzDE6CC7EoAjpleg6LdaD68rTTvGKCn6Gzve-ZdvfC-TZTD73MI42QFyyYVJTppVak4LKPdqnmHOCwWyTn8pmhhJTwzIvYZkaljmEVXQfDiOWbgL3T_WSTgE-7QEfhnqOx5hGZ2a7G2Mq9wi9z4b_f8YTRgioJw</recordid><startdate>20211117</startdate><enddate>20211117</enddate><creator>Liang, Kae-Woei</creator><creator>Lee, Wen-Jane</creator><creator>Lee, Wen-Lieng</creator><creator>Wu, Jen-Pey</creator><creator>Sheu, Wayne H-H</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20211117</creationdate><title>Shorter (GT)n repeats in the haem-oxygenase 1 gene promoter are associated with better mid-term survival in subjects with coronary artery disease and abnormal ejection fraction</title><author>Liang, Kae-Woei ; Lee, Wen-Jane ; Lee, Wen-Lieng ; Wu, Jen-Pey ; Sheu, Wayne H-H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-556358509d2e6eebbf8e9c179a502d21f4344f600c64bb847fdbbbb8d63bf8e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Coronary artery disease (CAD)</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary Artery Disease - mortality</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Dinucleotide Repeats - genetics</topic><topic>Female</topic><topic>Gene Expression Regulation</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>haem oxygenase (HO)-1</topic><topic>Heme Oxygenase-1 - genetics</topic><topic>HMOX1</topic><topic>Humans</topic><topic>left ventricular ejection fraction</topic><topic>Male</topic><topic>Middle Aged</topic><topic>promoter polymorphism</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Retrospective Studies</topic><topic>Stroke Volume - genetics</topic><topic>Stroke Volume - physiology</topic><topic>Survival Analysis</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Kae-Woei</creatorcontrib><creatorcontrib>Lee, Wen-Jane</creatorcontrib><creatorcontrib>Lee, Wen-Lieng</creatorcontrib><creatorcontrib>Wu, Jen-Pey</creatorcontrib><creatorcontrib>Sheu, Wayne H-H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Kae-Woei</au><au>Lee, Wen-Jane</au><au>Lee, Wen-Lieng</au><au>Wu, Jen-Pey</au><au>Sheu, Wayne H-H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shorter (GT)n repeats in the haem-oxygenase 1 gene promoter are associated with better mid-term survival in subjects with coronary artery disease and abnormal ejection fraction</atitle><jtitle>Biomarkers</jtitle><addtitle>Biomarkers</addtitle><date>2021-11-17</date><risdate>2021</risdate><volume>26</volume><issue>8</issue><spage>732</spage><epage>736</epage><pages>732-736</pages><issn>1354-750X</issn><eissn>1366-5804</eissn><abstract>Haem oxygenase (HO)-1 is a rate-limiting enzyme for degrading haem into carbon monoxide. Subjects with longer GT repeats in the HO-1 gene (HMOX1) promoter are more likely to have coronary artery disease (CAD) and cardiovascular events.
We retrospectively enrolled CAD subjects with an abnormal ejection fraction (EF) <50% from our catheterisation data (N = 670). Polymerase chain reactions were performed for amplifying the HMOX1 promoter GT repeating segment to determine the number of repeats.
In a median follow-up period of 40 months, 213 patients died. The distribution of genotype for HMOX1 promoter GT repeating segments SS, SL, and LL were significantly different (p < 0.001) between the dead (44.6%, 36.2%, 19.2%, respectively) and the survived (53.8%, 37.4%, 8.8%, respectively) (S allele: ≤30 repeats, L allele: >30 repeats). In Cox regression analysis, carrier of S allele (hazard ratio 0.665, p = 0.027), a higher EF (hazard ratio 0.037, p = 0.001), and revascularization with PCI were all negatively associated with all-cause death in subjects with CAD and abnormal EF.
Carrier of shorter (GT)
n
repeats of HMOX1 gene promoter was negatively correlated with death events in CAD patients with abnormal EF.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>34634993</pmid><doi>10.1080/1354750X.2021.1992650</doi><tpages>5</tpages></addata></record> |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Aged Coronary artery disease (CAD) Coronary Artery Disease - genetics Coronary Artery Disease - mortality Coronary Artery Disease - physiopathology Dinucleotide Repeats - genetics Female Gene Expression Regulation Gene Frequency Genotype haem oxygenase (HO)-1 Heme Oxygenase-1 - genetics HMOX1 Humans left ventricular ejection fraction Male Middle Aged promoter polymorphism Promoter Regions, Genetic - genetics Retrospective Studies Stroke Volume - genetics Stroke Volume - physiology Survival Analysis Survival Rate |
| title | Shorter (GT)n repeats in the haem-oxygenase 1 gene promoter are associated with better mid-term survival in subjects with coronary artery disease and abnormal ejection fraction |
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