Improvement of language functions in a chronic non-fluent post-stroke aphasic patient following bilateral sequential theta burst magnetic stimulation

In chronic non-fluent aphasia patients, inhibition of the intact right hemisphere (RH), by transcranial magnetic stimulation (TMS) or similar methods, can induce improvement in language functions. The supposed mechanism behind this improvement is a release of preserved left hemisphere (LH) language...

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Bibliographic Details
Published in:Neurocase 2015-03, Vol.21 (2), p.244-250
Main Authors: Vuksanovic, Jasmina, Jelic, Milan B, Milanovic, Sladjan D, Kacar, Katarina, Konstantinovic, Ljubica, Filipovic, Sasa R
Format: Article
Language:English
Subjects:
aphasia
Aphasia - etiology
Aphasia - therapy
Broca Area - physiopathology
Chronic Disease
Humans
interhemispheric interaction
Language
Magnetic Field Therapy - methods
Male
Middle Aged
propositional speech
Recovery of Function
rehabilitation
semantic fluency
stroke
Stroke - complications
transcranial magnetic stimulation
verbal learning
Verbal Learning - physiology
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Summary:In chronic non-fluent aphasia patients, inhibition of the intact right hemisphere (RH), by transcranial magnetic stimulation (TMS) or similar methods, can induce improvement in language functions. The supposed mechanism behind this improvement is a release of preserved left hemisphere (LH) language networks from RH transcallosal inhibition. Direct stimulation of the damaged LH can sometimes bring similar results too. Therefore, we developed a novel treatment approach that combined direct LH (Broca's area (BA)) stimulation, by intermittent theta burst stimulation (TBS), with homologue RH area's inhibition, by continuous TBS. We present the results of application of 15 daily sessions of the described treatment approach in a right-handed patient with chronic post-stroke non-fluent aphasia. The intervention appeared to improve several language functions, but most notably propositional speech, semantic fluency, short-term verbal memory, and verbal learning. Bilateral TBS modulation of activation of the language-related areas of both hemispheres seems to be a feasible and promising way to induce recovery in chronic aphasic patients. Due to potentially cumulative physiological effects of bilateral stimulation, the improvements may be even greater than following unilateral interventions.
ISSN:1355-4794
1465-3656
DOI:10.1080/13554794.2014.890731