Quantification of 5-HT 1A and 5-HT 2A receptor Binding in Depressed Suicide Attempters and Non-Attempters

To determine serotonin system abnormalities related to major depression or previous suicidal behavior. [ C]WAY100635, [ F]altanserin and positron emission tomography were used to compare 5-HT and 5-HT binding in MDD patients divided into eight past suicide attempters (>4yrs prior to scanning) and...

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Bibliographic Details
Published in:Archives of suicide research 2019-01, Vol.23 (1), p.122-133
Main Authors: Mann, J John, Metts, Allison V, Ogden, R Todd, Mathis, Chester A, Rubin-Falcone, Harry, Gong, Zhiqun, Drevets, Wayne C, Zelazny, Jamie, Brent, David A
Format: Article
Language:English
Subjects:
Adult
Brain - diagnostic imaging
Brain - metabolism
Correlation of Data
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - metabolism
Depressive Disorder, Major - psychology
Female
Humans
Male
Positron-Emission Tomography - methods
Psychiatric Status Rating Scales
Receptor, Serotonin, 5-HT1A - metabolism
Receptor, Serotonin, 5-HT2A - metabolism
Reproducibility of Results
Suicide, Attempted - psychology
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Summary:To determine serotonin system abnormalities related to major depression or previous suicidal behavior. [ C]WAY100635, [ F]altanserin and positron emission tomography were used to compare 5-HT and 5-HT binding in MDD patients divided into eight past suicide attempters (>4yrs prior to scanning) and eight lifetime non-attempters, and both groups were compared to eight healthy volunteers. The two receptor types differed in binding pattern across brain regions from each other, but there were no differences in binding between healthy volunteers and the two depressed groups or between depressed suicide attempters and non-attempters. No effects of depression severity or lifetime aggression were observed for either receptor. Limitations of this study include small sample size and absence of high lethality suicide attempts in the depressed attempter group. No trait-like binding correlations with past suicide attempt or current depression were observed. Given the heterogeneity of nonfatal suicidal behavior, a larger sample study emphasizing higher lethality suicide attempts may find the serotonin biological phenotype seen in suicide decedents.
ISSN:1381-1118
1543-6136
DOI:10.1080/13811118.2017.1417185