Effects of co-exposure to imidacloprid and gibberellic acid on redox status, kidney variables and histopathology in adult rats

• Published in: Archives of physiology and biochemistry 2018-05, Vol.124 (2), p.175-184
• Main Authors: Lafi, Bornia, Chaâbane, Mariem, Elwej, Awatef, Grati, Malek, Jamoussi, Kamel, Mnif, Hela, Boudawara, Tahia, Ketata Bouaziz, Hanen, Zeghal, Najiba
• Format: Article
• Language: English
• Subjects: Administration, Oral; Animals; Biomarkers - blood; Biomarkers - metabolism; Blood Urea Nitrogen; Drug Interactions; Gibberellins - administration & dosage; Gibberellins - toxicity; Insecticides - administration & dosage; Insecticides - toxicity; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Kidney - physiopathology; Lipid Peroxidation - drug effects; Metallothionein - metabolism; Neonicotinoids - administration & dosage; Neonicotinoids - toxicity; Nitro Compounds - administration & dosage; Nitro Compounds - toxicity; Organ Size - drug effects; Oxidation-Reduction; Oxidative Stress - drug effects; Oxidoreductases - metabolism; Plant Growth Regulators - toxicity; Poisoning - etiology; Poisoning - physiopathology; Protein Carbonylation - drug effects; Random Allocation; Rats, Wistar; Renal Insufficiency - etiology; Renal Insufficiency - metabolism; Renal Insufficiency - pathology; Renal Insufficiency - physiopathology; Weight Gain - drug effects
• ISSN: 1381-3455; 1744-4160
• DOI: 10.1080/13813455.2017.1371195

Data on the individual nephrotoxic effects of imidacloprid (IMI) and gibberellic acid (GA ) are scarce. Moreover, there is a lack of information about their combined effects on the renal tissue. Our study investigated the effects of IMI and GA separately or together on rats kidney. IMI (64 mg/kg bw) was given for 3 weeks by gavage either individually or in combination with GA (200 mg/L) via drinking water. IMI associated or no with GA increased the levels of kidney malondialdehyde, advanced oxidation protein products, protein carbonyls and metallothionein, plasma creatinine, urea, blood urea nitrogen and lactate dehydrogenase activity. A decline of kidney uric acid level and antioxidant status was also observed. All these changes were supported by histopathological observations. Our results highlighted the role of IMI and/or GA -induced nephrotoxicity. Co-exposure to IMI and GA exhibited synergism in biochemical kidney variables and histopathology and antagonism in physical and morphological parameters.