Triangle collaboration assessment of autophagy, ER stress and hypoxia in leukemogenesis: a bright perspective on the molecular recognition of B-ALL

B-lineage acute lymphoblastic leukemia (B-ALL) is the most common acute leukemia in childhood and adults, which caused by many various crystalline and unclear agents. Owning to this matter, no significant progress has been made in the patients-recovery. Recently, autophagy pathway is considered as a...

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Bibliographic Details
Published in:Archives of physiology and biochemistry 2021-05, Vol.127 (3), p.285-289
Main Authors: Feizi, Fatemeh, Allahbakhshian Farsani, Mehdi, Mirzaeian, Amin, Takhviji, Vahide, Hajifathali, Abbas, Hossein Mohammadi, Mohammad
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
autophagy
BECN1
ERN1
signalling pathway
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Summary:B-lineage acute lymphoblastic leukemia (B-ALL) is the most common acute leukemia in childhood and adults, which caused by many various crystalline and unclear agents. Owning to this matter, no significant progress has been made in the patients-recovery. Recently, autophagy pathway is considered as an ambiguous agent in leukemia evaluation. We aim to discover the expression levels of upstream autophagy-regulating genes in newly diagnosed B-ALL patients. In B-ALL group, BECN1, HIF1A and ERN1 expressions were significantly down-regulated, while BCL2 expression was up-regulated compared to the control group (p 
ISSN:1381-3455
1744-4160
DOI:10.1080/13813455.2019.1635163