Does irisin has neuroprotective effect against diabetes induced neuropathy in male rats?

We aimed to investigate the contribution of irisin in the neuroprotective process of exercise training in diabetic rats. Serum irisin levels, thermal and mechanical pain thresholds and intracellular calcium ([Ca 2+ ] i ) levels in sensory neurons were measured at different time intervals during the...

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Bibliographic Details
Published in:Archives of physiology and biochemistry 2023-03, Vol.129 (2), p.439-448
Main Authors: Kalkan, Ömer Faruk, Aktaş, Osman, Sürmeneli, Yunus Emre, Alver, Ahmet, Özcan, Mete, Şahin, Zafer
Format: Article
Language:English
Subjects:
Animals
calcium
Diabetes Mellitus, Experimental - complications
Diabetes Mellitus, Experimental - therapy
Exercise
Fibronectins
irisin
Male
neurodegeneration
neuropathic pain
Neuroprotective Agents - pharmacology
Pain Threshold
Physical Conditioning, Animal - physiology
Rats
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Summary:We aimed to investigate the contribution of irisin in the neuroprotective process of exercise training in diabetic rats. Serum irisin levels, thermal and mechanical pain thresholds and intracellular calcium ([Ca 2+ ] i ) levels in sensory neurons were measured at different time intervals during the eight weeks of exercise sessions for the control, non-exercise diabetics (3 groups) and exercise performing (low and high intensity groups) diabetic rats (n = 7-10 for all groups). Non-exercise diabetic groups were treated with irisin in different doses (1, 10 and 20 µg/kg respectively). Recovered pain thresholds at the end of the exercise sessions (p 
ISSN:1381-3455
1744-4160
DOI:10.1080/13813455.2020.1835985