Achieving simplified disease activity index remission in patients with active rheumatoid arthritis is associated with subsequent good functional and structural outcomes in a real-world clinical setting under a treat-to-target strategy

Objective: To verify predictive validity of simplified disease activity index (SDAI) remission for subsequent functional and structural outcomes in real-world clinical settings under a treat-to-target strategy (T2T). Methods: In this multicenter, prospective cohort study, T2T was implemented in rheu...

Full description

Saved in:
Bibliographic Details
Published in:Modern rheumatology 2017-09, Vol.27 (5), p.811-819
Main Authors: Hirano, Fumio, Yokoyama, Waka, Yamazaki, Hayato, Amano, Koichi, Kawakami, Atsushi, Hayashi, Taichi, Tamura, Naoto, Yasuda, Shinsuke, Dobashi, Hiroaki, Fujii, Takao, Ito, Satoshi, Kaneko, Yuko, Matsui, Toshihiro, Okuda, Yasuaki, Saito, Kazuyoshi, Suzuki, Fumihito, Yoshimi, Ryusuke, Sakai, Ryoko, Koike, Ryuji, Kohsaka, Hitoshi, Miyasaka, Nobuyuki, Harigai, Masayoshi
Format: Article
Language:English
Subjects:
Adult
Aged
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - diagnosis
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - physiopathology
Female
Health assessment questionnaire
Humans
Japan
Male
Middle Aged
Modified Sharp score
Patient Acuity
Predictive Value of Tests
Prognosis
Prospective Studies
Recovery of Function
Remission Induction - methods
Rheumatoid arthritis
Severity of Illness Index
Simplified disease activity index
Treat-to-target
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To verify predictive validity of simplified disease activity index (SDAI) remission for subsequent functional and structural outcomes in real-world clinical settings under a treat-to-target strategy (T2T). Methods: In this multicenter, prospective cohort study, T2T was implemented in rheumatoid arthritis (RA) patients with moderate-to-high disease activity. SDAI or clinical disease activity index (CDAI) was assessed every 12 weeks, and treatment was adjusted to achieve clinical remission or low disease activity (LDA). Multivariate logistic regression models were used to examine the associations of SDAI remission (≤3.3) at week 24 with the health assessment questionnaire-disability index (HAQ-DI) ≤ 0.5 or with the delta van der Heijde-modified total Sharp score (ΔvdH-mTSS) 
ISSN:1439-7595
1439-7609
DOI:10.1080/14397595.2016.1265726